POSSIBILITIES OF ANTIOXIDANT THERAPY, DIRECTED ON RESTRICTION OF THE ORGANS DISORDERS IN EARLY PHASE OF AN ACUTE NECROTIC PANCREATITIS
In the investigation 49 persons were included, in whom an acute necrotic pancreatitis was diagnosed. In 26 patients (control group) аntioxidant therapy was not conducted, in 23 (the main group) mexidol was applied in the intensive therapy complex for an acute pancreatitis early phase. There were investigated the oxidant system state in the patients on the 7th day from the disease beginning, the indices of the systemic inflammatory response syndrome (SIRS), the organs disorders rate. Mexidol application have promoted the SIRS severity reduction, what have correlated with the intensity reduction in the proteins peroxidal oxidation (PPO, r=0.441, p=0.035) and the lipids peroxidal oxidation (LPO, r=0.564, p=0.005), as well as the severity depression in functional state of the glutathione-dependent system of antioxidant defense (р< 0.05). Inclusion of mexidol in the intensive therapy complex in patients, suffering necrotic acute pancreatitis,have promoted reduction of the organ disorders rate in early phase of the disease by 32.9%, comparing with such in a control (р = 0.022), including, respiratory system - by 23.7% (р = 0.028), cardio-vascular - by 27.7% (р = 0.014), hepatic - by 31.3% (р = 0.012).
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