SEPSIS IN PATIENTS WITH COMPLICATED SYNDROME OF DIABETIC FOOT – ОXIDANT STRESS OF ORGANISM

  • S. D. Shapoval Zaporizhzhya Medical Academy of Postgraduate Education
  • О. V. Тrybushnyi Zaporizhzhya Medical Academy of Postgraduate Education
  • І. L. Savon Zaporizhzhya Medical Academy of Postgraduate Education
Keywords: diabetic foot syndrome, sepsis, peroxidal oxidation of lipids, оxidant stress

Abstract

Introduction. Purulent diseases are noted in more than 35% of patients in surgical stationaries, of whom a special group is presented when sepsis occurs on the complicated diabetic foot syndrome (DFS) background. The organism reaction towards septic process presents as changes in metabolic processes, in regulation of which peroxidal oxidation of lipids (POL) and system of antioxidant defense (SAD) play significant role.

Маterials and methods. There were examined in dynamics 724 patients, suffering complicated DFS. The POL state was estimated, basing on analysis of its primary and secondary products – dienic conjugates, malonic dyaldehyde, and Schiff bases.

Results. There was established, that in patients, suffering complicated DFS or sepsis, the changes in the POL products contentin the blood sera while admittance to hospital have appeared trustworthy (р< 0.05) in sepsis, and more pronounced, than in complicated DFS without sepsis.

Discussion. Аnalysis of the data obtained witnesses, that the sepsis course severity in patients with complicated DFS depends on the state of a free-radical oxidation of lipids. Results of the investigation also trusts, that primary and secondary products of POL constitute objective markers of the endogenous intoxication severity and determine the organism oxidant stress. In system of complex therapy in such patients antioxidants must be applied as one of variants of pathogenetically substantiated intensive therapy.

References

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Published
2017-11-24
How to Cite
Shapoval, S. D., ТrybushnyiО. V., & SavonІ. L. (2017). SEPSIS IN PATIENTS WITH COMPLICATED SYNDROME OF DIABETIC FOOT – ОXIDANT STRESS OF ORGANISM. Klinicheskaia Khirurgiia, (10), 41-43. https://doi.org/10.26779/2522-1396.2017.10.41
Section
General Problems of Surgery