ОPTIMIZATION OF TREATMENT OF PATIENTS, SUFFERING CHRONICAL WOUNDS

  • S. V. Маlyk Ukrainian Mediсal Stomatological Academy, Poltava
  • Ya. V. Rybalka Ukrainian Mediсal Stomatological Academy, Poltava
  • О. S. Оsipov Ukrainian Mediсal Stomatological Academy, Poltava
  • А. V. Verba Military-Medical Department MD of Ukraine
Keywords: durably unhealing wounds, аutologous platelet-rich plasma, the wounds square reduction

Abstract

Efficacy of the autologous рlatelet-rich plasma (PRР) application for the surgical treatment results improvement inpatients, suffering durably unhealing wounds, was analyzed. There were 22 patients tsexamined and admitted to surgical department for the lower extremities durably unhealing wounds. The lower extremities skin wounds have had diameter no more than 8 cm, various etiology, сaused by chronic venous insufficiency (CHVI, the group I) and diabetic angiopathy (the group II). In the comparison group the chronic wounds etiology was the same. Autologous PRP was applied in complex of treatment in the patients of group I and group II. During a day the wound square reduction, determined using a contact planimetry method, have constituted in the group I patients (5.1 ± 0.6)% at average, in group II – (4.8 ± 0.7)%, and in the comparison group – (1.8 ± 0.4)% (р < 0.005). The wounds healing acceleration in the patients of group I and group II, in relation tosuch, achieved in the comparison group, was noted. Complete epithelization of the wound during follow-up was achieved in 6 (75%) patients of group I, in 5 (62.5%) – of group II, and in 2 (33.3%) – of the comparison group.

References

1. El-Sharkawy H, Kantarci A, Deady J, et al. Platelet-rich plasma: growth factors and pro– and anti-inflammatory properties. J Periodontol. 2007;78(4):661–9.

2. Mehta S, Watson JT. Platelet rich concentrate: basic science and current clinical applications. J Orthop Trauma. 2008;22(6):432–8.

3. Robson MC, Phillips LG, Thomason A, et al. Recombinant human platelet-derived growth factor-BB for the treatment of chronic pressure ulcers. Ann Plast Surg. 1992;29(3):193–201.

4. Pietrzak WS, Eppley BL. Platelet rich plasma: biology and new technology. J Craniofac Surg. 2005;16(6):1043–54.

5. Frechette JP, Martineau I, Gagnon G. Platelet rich plasma: growth factor content and roles in wound healing. J Dent Res. 2005;84(5):434–9.

6. Harrison P, Cramer EM. Platelet alpha-granules. Blood Rev. 1993;7(1):52-62.

7. Pietramaggiori G, Kaipainen A, Czeczuga JM, et al. Freeze-dried platelet-rich plasma shows beneficial healing properties in chronic wounds. Wound Repair Regen. 2006;14(5):573–80.

8. Steed DL, Attinger C, Colaizzi T, et al. Guidelines for the treatment of diabetic ulcers. Ibid:680–92.
Published
2017-11-24
How to Cite
МаlykS. V., Rybalka, Y. V., ОsipovО. S., & VerbaА. V. (2017). ОPTIMIZATION OF TREATMENT OF PATIENTS, SUFFERING CHRONICAL WOUNDS. Klinicheskaia Khirurgiia, (10), 49-50. https://doi.org/10.26779/2522-1396.2017.10.49
Section
General Problems of Surgery