IMPACT OF THE BILIARY DUCTS DECOMPRESSION ON DYNAMICS OF BILE PRODUCTION AND BILE EXCRETION AFTER EXPERIMENTAL CHOLESTASIS OF DIFFERENT DURATION
Abstract
Objective.To investigate the impact of decompression of biliary ducts towards the bile production and excretion hepatic function after experimental cholestasis of different duration.
Маterials and methods. In experiment on nonline white rats the obturation jaundice was simulated and indices of biliary production and excretion were studied.
Results. After cholestasis during 3 days and recanalization of common biliary duct the restoration of biliary production and biliary excretion function of the liver occurs in 5 days; after 7 days of cholestasis – in 7 days; and after 14 days of cholestasis–inhibition of hepatic functional state in all terms after recanalization of common biliary duct with transient improvement is observed in 9 days.
Discussion. Recanalization of common biliary ductis accompanied by reduction in the common biliary acids and cholesterol contents in bile, by enhancement of the bile lithogenic properties and by slowing-down of its outflow. Dynamics and intensityof the disorders revealed depend upon the obturation duration, they are maximal after 14 days of cholestasis.
Conclusion. Іntensity of disorders in the hepatic functional state depends upon cholestasis duration and progresses from the 3d to14th day of cholestasis.
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