IMPACT OF THE BILIARY DUCTS DECOMPRESSION ON DYNAMICS OF BILE PRODUCTION AND BILE EXCRETION AFTER EXPERIMENTAL CHOLESTASIS OF DIFFERENT DURATION

Keywords: оbturation cholestasis, recanalization of common biliary duct, bile production, bile excretion, еxperiment

Abstract

Objective.To investigate the impact of decompression of biliary ducts towards the bile production and excretion hepatic function after experimental cholestasis of different duration.

Маterials and methods. In experiment on nonline white rats the obturation jaundice was simulated and indices of biliary production and excretion were studied.

Results. After cholestasis during 3 days and recanalization of common biliary duct the restoration of biliary production and biliary excretion function of the liver occurs in 5 days; after 7 days of cholestasis – in 7 days; and after 14 days of cholestasis–inhibition of hepatic functional state in all terms after recanalization of common biliary duct with transient improvement is observed in 9 days.

Discussion. Recanalization of common biliary ductis accompanied by reduction in the common biliary acids and cholesterol contents in bile, by enhancement of the bile lithogenic properties and by slowing-down of its outflow. Dynamics and intensityof the disorders revealed depend upon the obturation duration, they are maximal after 14 days of cholestasis.

Conclusion. Іntensity of disorders in the hepatic functional state depends upon cholestasis duration and progresses from the 3d to14th day of cholestasis.

Author Biographies

О. І. Dzyubanovskyi, Теrnopil State Medical University named after І. Ya. Gorbachevskyi

Assistant of department of surgery with urology №1 by. L.Ya. Kovalchuk I. Horbachevsky Ternopil State Medical University. Address: Klinichna Street, 1, Ternopil, Tel.: (0352) 966088904.

А. А. Gudyma, Теrnopil State Medical University named after І. Ya. Gorbachevskyi

MD, professor. Head of department of disaster medicine and military medicine I. Horbachevsky Ternopil State Medical University. Address: Doroshenka Street, 7, Ternopil, Tel.: (0352)43 11 33

References

1. Badretdinova AR. Analiz vozrastno-polovoy struktury bolnykh zhelchekamennoy boleznyu, idushchikh na planovuyu kholetsistektomiyu. Prakticheskaya meditsina. 2011;(50):60. [In Russian].

2. Borisenko VB, Belov SG, Gorgol NI. Dinamika morfologicheskikh izmeneniy kholedokha, pecheni i drugikh vnutrennikh organov pri modelirovanii mekhanicheskoy zheltukhi v eksperimente. Kharkіvska khіrurgіchna shkola. 2012;(1):46-52. [In Russian].

3. Ratchyk VM, Kosynskyi АV, Prolom NV. Kliniko-laboratorni osoblyvosti eksperymentalnoho kholestazu. Klinichna khirurhiia. 2007;(2):81. [in Ukrainian].

4. Smirnova NG, Chefu SG, Kovalenko AL, Vlasov TD. Vliyanie infuzionnogo gepatoprotektora remansol na funktsіyu pecheni krys na modeli obturatsionnoy zheltukhi. Eksperimentalnaya i klinicheskaya farmakologiya. 2010;73(9):24-7. [In Russian].

5. Hnatiuk MS, Klishch IM, Halei MM. Morfolohichni zminy pechinky ta yikh korektsiia pry zmodelovanii obturatsiinii zhovtianytsi. Shpytalna khirurhiia. 2008;(4):78–82. [in Ukrainian].

6. Orel IuM, Dziubanovskyi OI, Shkrobot LV. Strukturni zminy pechinkovoi tkanyny v umovakh zmodelovanoho kholestazu i pislia yoho likvidatsii. Shpytalna khirurhiia. Zhurnal imeni L Ia Kovalchuka. 2016;(2):45-9. [in Ukrainian].

7. Aller MA, Duran M, Ortega L, Arias JL. Comparative study of macro- and microsurgical extrahepatic cholestasis in the rat. Microsurgery. 2004;24(6):442 – 7.

8. Stefanova OV. Doklinichni doslidzhennia likarskykh zasobiv: metodychni rekomendatsii K. Avitsenna; 2001. 528 s. [in Ukrainian]

9. Chekman IS, Posokhova KA, Beregovaya YeG. Mikrosomalnaya fermentnaya sistema orhanizma. Kiev; 1996. 80 s. [In Russian].

10. Dziubanovskyi OI. Vplyv dekompresii zhovchovyvidnykh shliakhiv na dynamiku protsesiv lipoperoksydatsii, antyoksydantnoho zakhystu i tsytolizu pislia eksperymentalnoho trydobovoho kholestazu. Visnyk naukovykh doslidzhen. 2016;(4):128-30. [in Ukrainian].

11. Drogovoz SM, Salnikova SI, Skakun NP, Slyshkov VV. Metodicheskie rekomendatsii po eksperimentalnomu izucheniyu zhelchegonnoy, kholespazmoliticheskoy, kholelitiaznoy i gepatoprotektornoy aktivnosti novykh lekarstvennykh veshchestv. Kyiv: FKMZ Ukrainy; 1994. 46 s. [In Russian].
Published
2017-11-24
How to Cite
DzyubanovskyiО. І., & GudymaА. А. (2017). IMPACT OF THE BILIARY DUCTS DECOMPRESSION ON DYNAMICS OF BILE PRODUCTION AND BILE EXCRETION AFTER EXPERIMENTAL CHOLESTASIS OF DIFFERENT DURATION. Klinicheskaia Khirurgiia, (10), 66-69. https://doi.org/10.26779/2522-1396.2017.10.66
Section
Experimental Investigations