Еfficacy of local application of antimicrobal preparations with the programmed access of antiseptic from the wound in patients with the burn trauma

Keywords: аntimicrobial preparations; аntiseptics; burns; wounds; healing of wounds

Abstract

Objective. To study dynamics of the cellular elements content and degree of microbial colonization (MC) of the burn wounds in acute period of the burn disease while application of antimicrobial composition (AMC) with programmed release of decametoxine.

Маtеrіаls and methods. Healing of the burn wounds of Degree ІІІ (3, 7, 14, 21-st day) was investigated cytologically (method of the wound imprints), microbiologically (quantitative, qualitative identification of microorganisms - МО). In the observation Group (n=32) the measures with programmed prolonged release of decametoxine were applied, and in the comparison Group (n=29) - povidone-iodine.

Results. A.baumannii, P. aeruginosa have colonized the burn wounds most frequently. Reduction of the wounds MC (14-th day - log 5.5 CFU (colony-forming unit)/ml; 21-st day - log 2.4 CFU/ml), early (3, 7-th day) increase of the phagocytic cells (p < 0.001), the marker’s regeneration (p < 0.05), and reduction of inflammatory component from 14-th day were established while application of the AMC. In the comparison Group a degenerative phagocytosis was determined on the 7-th day and prolongation of inflammatory component - on the 21-st day.

Conclusion. AMC application with programmed release of decametoxine reduces MC effectively, promotes acceleration of the wounds reparation.

Author Biographies

V. І. Nahaychuk, Vinnytsya National Medical University named after М. І. Pyrogov

Nahaychuk Vasyl' Ivanovych, - Doctor of medical sciences,
head of the burn department,
Vinnitsa Regional Clinical Hospital named after N. I. Pirogov,
Professor of the Department of General Surgery,
National Pirogov Memorial Medical University, Vinnytsya.
Address: 46 Pirogov Str., 21018, Vinnytsya, Ukraine,
+380(432) 56-23-74;

H. К. Paliy, Vinnytsya National Medical University named after М. І. Pyrogov

Paliy Hordiy Kindratovych - Doctor of Medical Sciences, Professor,
Professor of the Department of Microbiology,
National Pirogov Memorial Medical University, Vinnytsya.
Address: 56 Pirogov Str., 21018, Vinnytsya, Ukraine
E-mail: g_paliy@ukr.net
ORCID: http://orcid.org/0000-0002-4934-124X;

О. А. Nazarchuk, Vinnytsya National Medical University named after М. І. Pyrogov

Nazarchuk Oleksandr Adamovych - PhD, Senior Lecturer,
Department of Microbiology,
National Pirogov Memorial Medical University, Vinnytsya.
Address: 56 Pirogov Str., 21018, Vinnytsya, Ukraine, +380977293761
E-mail: nazarchukoa@gmai.com
ORCID: http://orcid.org/0000-0001-7581-0938

І. М. Vovk, Vinnytsya National Medical University named after М. І. Pyrogov

Vovk Iryna Mykolayivna - PhD, Associate Professor, Associate Professor of the Department of Microbiology, National Pirogov Memorial Medical University, Vinnytsya.
Address: 56 Pirogov Str., 21018, Vinnytsya, Ukraine
E-mail:, vovk.in2017@gmail.com
ORCID: http://orcid.org/0000-0001-8343-0724

D. V. Dmytriiev, Vinnytsya National Medical University named after М. І. Pyrogov

Dmytriiev Dmytro Valeriyevich - PhD, Associate Professor, Associate Professor of the Department of Anesthesiology, National Pirogov Memorial Medical University, Vinnytsya.
Address: 56 Pirogov Str., 21018, Vinnytsya, Ukraine
E-mail:, dmytrodmytriiev@gmail.com
http://orcid.org/0000-0002-8465-5965

References

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Published
2018-03-03
How to Cite
NahaychukV. І., PaliyH. К., NazarchukО. А., VovkІ. М., & Dmytriiev, D. V. (2018). Еfficacy of local application of antimicrobal preparations with the programmed access of antiseptic from the wound in patients with the burn trauma. Klinicheskaia Khirurgiia, 85(3), 52-56. https://doi.org/10.26779/2522-1396.2018.03.52
Section
General Problems of Surgery