Comparative analysis of dynamics of the spasticity level in paretic extremity of rat on background of open penetrating spinal cord trauma with durable persistence of biocompatible foreign body in vertebral channel

Keywords: open penetrating affection of spinal cord; posttraumatic spasticity; accretion and acceleration of the spasticity index accretion; dynamics; analysis

Abstract

Objective. To compare dynamics of the spasticity level in the rat paretic extremity on background of durable compression of traumatized spinal cord by foreign body.

Маterials and methods. As a primary numerical data the empirical material was applied, оbtained in some previous investigations (V. І. Tsymbalyuk et al, 2016, 2017), performed on mature white mongrel male rats, ageing 5.5 mo and body mass 300 g (іnbred line, breed deviated Wistar). Еxperimental groups: Group 1 (n=16) - a spinal cord trauma, Group 2 (n=10) - аnalogous spinal cord trauma and immediate implantation of foreign body into the affection zone. A left-sided half transsection on the Т11 level have constituted a simulation model. The Ashworth scale was applied for monitoring of the spasticity index of paretic extremity. A program package STATISTICA 10.0 was used to calculate statistically a weekly spasticity index accretion and the accretion acceleration.

Results. In Group1 the biggest accretion of the spasticity index of paretic extremity was observed during 2 - 4-th and 7-th week of experiment, and in Group 2 - during 1-st and 5-th weeks. The accretion of the spasticity index first phase in a Group 2 may be a consequence of glutamatergic impact on denervated motoneurons in context of compressive ischemia of a spinal cord tissue, a delay of another phase constitutes a consequence of the delayed realization of the spasticity mechanism, dependent on serotonin receptor 5-НТ.

Conclusion. A spinal cord compression by foreign body potentiates early glutamatergic mechanisms and delays manifestation of late, dependent on 5-НТ, mechanisms of spasticity.

Author Biographies

V. І. Tsymbaliuk, National Academy of Medical Sciences of Ukraine, Kyiv

Tsymbaliuk Vitaliy Ivanovych, MD, PhD, ScD,
National Academy of Sciences of Ukraine,
President;
12 Gertzen str., Kyiv 04050, Ukraine;
tel.: +38044483-12-53;
V.tsymbaliuk@i.ua;
ORCID: 0000-0003-3608-9679 (http://orcid.org/0000-0003-3608-9679)

V. V. Medvediev, Bogomolets National Medical University, Kyiv

Medvediev Volodymyr Viktorovych, PhD,
Bogomoletz National Medical University,
dep. of neurosurgery,
assistent prof.,
32 Platona Mayborody St., Kyiv-50, 04050, Ukraine;
tel.: +38044-483-12-53;
vavo2010@gmail.com;
ORCID: 0000-0001-7236-3191 (http://orcid.org/0000-0001-7236-3191)

Yu. Yu. Senchik, Kyiv Municipal Clinical Hospital of Urgent Medical Help

Senchik Yurii Yuriyovych, PhD,
Kyiv municipal clinical emergency hospital,
dep. of surgery of the spine and spinal cord, neurosurgeon,
3 Bratislavska Str., Kyiv-60, 02660, Ukraine;
tel.: +38044-527-69-69;
dr.senchyk@gmail.com;
ORCID: 0000-0001-9329-034X (http://orcid.org/0000-0001-9329-034X)

N. G. Draguntsova, Romodanov Institute of Neurosurgery, Kyiv

Draguntsova Natalya Gennadiyivna,
Romodanov Neurosurgery Institute,
laboratory of experimental neurosurgery,
32 Platona Mayborody St., Kyiv-50, 04050, Ukraine;
tel.: +38044 483-94-07;
natalya.exlab@gmail.com;
ORCID: 0000-0001-8624-0600 (http://orcid.org/0000-0001-8624-0600)

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Published
2018-03-03
How to Cite
TsymbaliukV. І., Medvediev, V. V., Senchik, Y. Y., & Draguntsova, N. G. (2018). Comparative analysis of dynamics of the spasticity level in paretic extremity of rat on background of open penetrating spinal cord trauma with durable persistence of biocompatible foreign body in vertebral channel. Klinicheskaia Khirurgiia, 85(3), 66-69. https://doi.org/10.26779/2522-1396.2018.03.66
Section
Experimental Investigations