Comparative analysis of dynamics of the spasticity level in paretic extremity of rat on background of open penetrating spinal cord trauma with durable persistence of biocompatible foreign body in vertebral channel
Objective. To compare dynamics of the spasticity level in the rat paretic extremity on background of durable compression of traumatized spinal cord by foreign body.
Маterials and methods. As a primary numerical data the empirical material was applied, оbtained in some previous investigations (V. І. Tsymbalyuk et al, 2016, 2017), performed on mature white mongrel male rats, ageing 5.5 mo and body mass 300 g (іnbred line, breed deviated Wistar). Еxperimental groups: Group 1 (n=16) - a spinal cord trauma, Group 2 (n=10) - аnalogous spinal cord trauma and immediate implantation of foreign body into the affection zone. A left-sided half transsection on the Т11 level have constituted a simulation model. The Ashworth scale was applied for monitoring of the spasticity index of paretic extremity. A program package STATISTICA 10.0 was used to calculate statistically a weekly spasticity index accretion and the accretion acceleration.
Results. In Group1 the biggest accretion of the spasticity index of paretic extremity was observed during 2 - 4-th and 7-th week of experiment, and in Group 2 - during 1-st and 5-th weeks. The accretion of the spasticity index first phase in a Group 2 may be a consequence of glutamatergic impact on denervated motoneurons in context of compressive ischemia of a spinal cord tissue, a delay of another phase constitutes a consequence of the delayed realization of the spasticity mechanism, dependent on serotonin receptor 5-НТ2С.
Conclusion. A spinal cord compression by foreign body potentiates early glutamatergic mechanisms and delays manifestation of late, dependent on 5-НТ2С, mechanisms of spasticity.
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