Surgical treatment of secondary hyperparathyrosis in patients with chronic renal disease
Abstract
Objective. To investigate efficacy of operative treatment for secondary hyperparathyrosis in patients, suffering chronic renal disease.
Маterials and methods. Retrospective investigation of results of operative interventions on parathyroid glands and clinic-laboratory indices in patients with secondary hyperparathyrosis were estimated.
Results. Using investigations of operative material of parathyroid glands in 62 patients, the following diagnosis were proved: diffuse hyperplasia - in 8 (12.9%, 95% trustworthy interval (TІ), 4.6 – 21.2%), microadenomatosis – in 14 (22.6%, 95% TІ 12.2 – 33.0%); macroadenoma – in 40 (64.5%, 95% TІ 52.6 – 76.4%). Of 40 patients with macroadenomas the tumors, consisting of main cells, were diagnosed in 32 (80%, 95% TІ 67.9 – 92.4%), оncocytic tumors – in 8 (20%, 95% TІ 7.6 – 32.4%). Odd’s ratio (OR) – 16.0; χ2 – 26.45; р < 0.0001.
Comparison of clinic-laboratory indices in 1, 6 and 12 mo in patients after operations on parathyroid glands аnd in those, to whom operative interventions were not performed, have had revealed statistically trustworthy results of normalization for levels of parathyroid hormone, calcium, phosphorus and alkaline phosphatase in the blood.
Conclusion. Surgical intervention for secondary hyperparathyrosis constitutes effective method of treatment, which promotes normalization of laboratory indices and prevents severe complications.
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