Surgical treatment of secondary hyperparathyrosis in patients with chronic renal disease

Keywords: secondary hyperparathyrosis; tertiary hyperparathyrosis; parathyroidectomy; chronic renal disease.

Abstract

Objective. To investigate efficacy of operative treatment for secondary hyperparathyrosis in patients, suffering chronic renal disease.

Маterials and methods. Retrospective investigation of results of operative interventions on parathyroid glands and clinic-laboratory indices in patients with secondary hyperparathyrosis were estimated.

Results. Using investigations of operative material of parathyroid glands in 62 patients, the following diagnosis were proved: diffuse hyperplasia - in 8 (12.9%, 95% trustworthy interval (TІ), 4.6 – 21.2%), microadenomatosis – in 14 (22.6%, 95% TІ 12.2 – 33.0%); macroadenoma – in 40 (64.5%, 95% TІ 52.6 – 76.4%). Of 40 patients with macroadenomas the tumors, consisting of main cells, were diagnosed in 32 (80%, 95% TІ 67.9 – 92.4%), оncocytic tumors – in 8 (20%, 95% TІ 7.6 – 32.4%). Odd’s ratio (OR) – 16.0; χ2 – 26.45; р < 0.0001.

Comparison of clinic-laboratory indices in 1, 6 and 12 mo in patients after operations on parathyroid glands аnd in those, to whom operative interventions were not performed, have had revealed statistically trustworthy results of normalization for levels of parathyroid hormone, calcium, phosphorus and alkaline phosphatase in the blood.

Conclusion. Surgical intervention for secondary hyperparathyrosis constitutes effective method of treatment, which promotes normalization of laboratory indices and prevents severe complications.

Author Biographies

R. P. Тkachenko, Scientific-Practical Centre for Prophylactic and Clinical Medicine State Directorate of Affairs, Kyiv

Tkachenko Rimma Petrivna - PhD,
scientific collaborator of the scientific miniinvasive surgery
Scientific-practical centre of preventive and clinical medicine; Kyiv, Verhnia street 5.
Phone: 044 284 6272.
e-mail: rimmatkachenko@i.ua
ORCID ID: orcid.org/0000-0003-3775-8002

О. G. Кuryk, Scientific-Practical Centre for Prophylactic and Clinical Medicine State Directorate of Affairs, Kyiv

Olena Georhiivna Kuryk PhD,
main scientific collaborator of the scientific miniinvasive surgery department
Scientific-practical centre of preventive and clinical medicine
Kyiv, Verhnia street 5.
Phone: 044 284 6272
e-mail: O_Kurik@ukr.net
ORCID ID: orcid.org /0000-0003-3093-4325

А. S. Golovko, Bogomolets National Medical University, Kyiv

Golovko Alla Sergiyivna – student
Bogomolets National Medical University;
Kyiv, Shevchenko boulevard 17.
Phone: 044 234 4062;
e-mail: golovko-alla@ukr.net
ORCID ID: orcid.org/0000-0003-2098-7140

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Published
2018-05-26
Section
General Problems of Surgery

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