The role of genetic investigations in diagnosis of diseases of temporo-mandibular joint
Abstract
Objective. In accordance to the genetic investigation results and their numerical value to confirm clinical diagnoses in patients for further adjustment of the treatment-prophylactic plan.
Маterials and methods. In the investigation 10 patients took part: 5 women and 5 men, ageing 25 - 50 yrs old. Analysis was conducted in laboratory of molecular– genetic investigations – Ltd «Germedtech», City of Odessa. The Dellaport’s method was applied for isolation and purification of deoxyribonucleic acid from buccal cells.
Results. Basing on results of the genes GSTM1, CoL2A1, MMP1, ER, IL1B, TNF analysis, taking part in metabolism of the joint osteo–cartilaginous tissue, a genetic risk of the diseases of the temporo-mandibular joint development was determined.
Conclusion. Basing on genetic investigation, concerning certain quantity of genetic markers and their analysis, clinical diagnoses were clarified and confirmed. Certain quantity of genetic markers and their numerical values permit to prognosticate the pathological process course, to conduct treatment and prophylactic measures and to elaborate individual protocol of treatment on this background in patients, suffering diseases of temporo-mandibular joint.
References
2. Zhelenina LA, Ivashhenko TЕ, Efimova NS. Polimorfizm genov semejstva glutation-S-transferazy (GST) pri bronhial'noj astme u detej. Allergologija. 2003;2:13–6. [In Russian].
3. Zazerskaja IE, Aseev MV, Kuznecova LV, Moskalenko MV. Analiz associacii allelej gena COL1A1 s razvitiem osteoporoza. Genetika. 2002;38(12):1699-703. [In Russian].
4. Pantsulaia I, Trofimov S, Kobyliansky E, Livshits G. Genetic and environmental influences on IL-6 and TNF-alpha plasma levels in apparently healthy general population. Cytokine. 2002;l9(3):138-46. DOI:10.1111/j.1365-2265.2006.02456.x
5. Timofeev AA. Rukovodstvo po cheljustno-licevoj hirurgii i hirurgicheskoj stomatologii. Kiev: OOO «ChervonaRuta-Turs»; 2004. 1062 s. [In Russian] ISBN 966-8607-00-7.
6. Rovetta G, Grignolo MC, Buffiini L. Prevalence of C282Y mutation in patients with rheumatoid arthritis and spondylarthritis. Int J Tissue React. 2002;24(3):105-9. PMID:12635863.
7. Kljajnrok M. Funkcional'nye rasstrojstva v dvigatel'noj chaste zhevatel'nogo apparata. L'vov: «GalDent»; 2015. 256 s.[In Russian] ISBN 978-966-7337-62-9.
8. Alvim-Pereira F, Alvim-Pereira C, Trevilatto P. The Current Knowledge of Genetic Susceptibility Influencing Dental Implant Outcomes. The International journal of oral & maxillofacial implants. 2011:347-367. DOI: 10.5772/18065.
9. Grant SF, Reid DM, Blake G. Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene. Nat Genet. 1996;14:203–5. DOI:10.1038/ng1096-203.
Copyright (c) 2018 TOV "Liga-inform"
This work is licensed under a Creative Commons Attribution 4.0 International License.