The role of genetic investigations in diagnosis of diseases of temporo-mandibular joint

Keywords: diseases of temporo-mandibular joint; patients; results of genetic investigation.

Abstract

Objective. In accordance to the genetic investigation results and their numerical value to confirm clinical diagnoses in patients for further adjustment of the treatment-prophylactic plan.

Маterials and methods. In the investigation 10 patients took part: 5 women and 5 men, ageing 25 - 50 yrs old. Analysis was conducted in laboratory of molecular– genetic investigations – Ltd «Germedtech», City of Odessa. The Dellaport’s method was applied for isolation and purification of deoxyribonucleic acid from buccal cells.

Results. Basing on results of the genes GSTM1, CoL2A1, MMP1, ER, IL1B, TNF analysis, taking part in metabolism of the joint osteo–cartilaginous tissue, a genetic risk of the diseases of the temporo-mandibular joint development was determined.

Conclusion. Basing on genetic investigation, concerning certain quantity of genetic markers and their analysis, clinical diagnoses were clarified and confirmed. Certain quantity of genetic markers and their numerical values permit to prognosticate the pathological process course, to conduct treatment and prophylactic measures and to elaborate individual protocol of treatment on this background in patients, suffering diseases of temporo-mandibular joint.

Author Biographies

К. А. Semenov, Dnepropetrovsk Medical Academy, Krivoy Rog

Semenov Konstantin Arnoldovich PhD Associate Professor
Department of Stomatology, Dnepropetrovsk Medical Academy
49000 str Vladimir Vernadskogo, 9, Dnipro, Dnipropetrovsk region,
Phone: 056 713 5257
k.75semenov@gmail.com,
http://orcid.org/0000-0001-7094-9316

О. V. Denga, Institute of Stomatology and the Jaw-Fascial Surgery, Odessa

Denga Oksana Vasilievna PhD, Professor,
Head of the Department of Epidemiology and Prevention of Major Dental Diseases,
Institute of Stomatology and Maxillofacial Surgery
street Rishelievskaya, 11, Odessa, Odessa region, 65000
Phone: 048 728 2475
denga@optima.com.ua,
http://orcid.org/0000-0002-8630-9943

V. N. Gorokhivsky, Оdessa National Medical University

Gorokhivsky Vladimir Nesterovich PhD, Senior Researcher
Head of the Department of Orthodontics
Odessa National Medical University
street Rishelievskaya, 11, Odessa, Odessa region, 65000
Phone: 048 728 2475
kudliuk.galina@gmail.com,
http://orcid.org/0000-0002-9958-1823

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Published
2018-05-26
Section
General Problems of Surgery