Comparative characteristics of quality of life in patients, suffering locally-spread mammary gland cancer after conduction of regional and intravenous chemotherapy

Keywords: locally-spread mammary gland cancer; complex treatment; intraarterial polychemotherapy; systemic polychemotherapy; quality of life.

Abstract

Objective. Investigation of quality of life (QL) in patients, suffering inoperable forms (locally-spread) of mammary gland cancer (MGC), before and after conduction of neoadjuvant courses of systemic polychemotherapy (SPCHTH) and selective intraarterial polychemotherapy (SIAPCHTH) in combination with SPCHTH.

Маterials and methods. Complex treatment was conducted in 154 patients, suffering locally-spread MGC T4A-DN0-3M0 in a period 2000 -2017 yrs, on base of Donetsk Regional Antitumoral Centre and The University Clinic of Odessa National Medical University. All the patients were divided into two groups. Tо Group I (control) were included 65 patients, suffering inoperable forms of a locally-spread MGC, to whom as a neoadjuvant course a SPCHTH was conducted; and to the Group II (investigating) - 89 patients, suffering inoperable forms of locally-spread MGC, to whom a SIAPCHTH was conducted as a neoadjuvant course.

Results. Through the period of treatment a wave-like dynamics of the quality of life index was observed, which indicated a definite advantage of SIAPCHTH over SPCHTH. A limited statistically trustworthy difference in favor of regional polychemotherapy was formed between the Groups of patients in accordance to the quality of life index.

Conclusion. Investigation of quality of life constitutes a secure, informative and economic method of estimation of a patient state of health on the groupings and the individuals levels. In oncological investigations the QL assessment constitutes an important criterion of the treatment efficacy estimation and has a prognostic significance. Estimation of quality of life in clinical investigations improves the investigation quality itself.

Author Biographies

Yu. V. Dumanskiy, Donetsk National Medical University, Krasnyi Lyman

Dumanskiy Yuriy Vasilevich
Professor of the oncology and radiology
department in Donetsk medical university
84404 Donetsk region, Liman, Privokzalnaia street 27
oncologdopc@gmail.com
ORCID: http://orcid.org/0000-0003-2293-0869
+380992234015

O. V. Bondar, Odessa National Medical University

Bondar Oleksandr Vadimovich, Phd.,
heard of the mammology department
University clinic of Odesa medical university
65009 Odessa region, Odessa, 8 Tinista str.
ovbondar0708@gmail.com
ORCID: http://orcid.org/0000-0001-8746-1878
+380660658689

O. I. Tkachenko, Odessa National Medical University

Tkachenko Oleksandr Ivanovich, Professor,
heard of surgery department №4 with oncology department
Odesa medical university
65009 Odessa region, Odessa, 8 Tinista str.
doctortkachenko@i.ua
+380503366933

Ye. A. Stoliarchuk, Odessa National Medical University

Stoliachuk Evhenii Anatoliiovich
Resident of the surgical department
65009 Odessa region, Odessa, 8 Tinista str.
engenes100@gmail.com
ORCID: http://orcid.org/0000-0003-0561-5357
+380939834719

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Published
2018-07-26
How to Cite
Dumanskiy, Y. V., Bondar, O. V., Tkachenko, O. I., & Stoliarchuk, Y. A. (2018). Comparative characteristics of quality of life in patients, suffering locally-spread mammary gland cancer after conduction of regional and intravenous chemotherapy. Klinicheskaia Khirurgiia, 85(6), 55-59. https://doi.org/10.26779/2522-1396.2018.06.55
Section
General Problems of Surgery