Comparative estimation of diagnostic informativity of a fine-needle aspiration biopsy and pathomorphological investigation of nodal thyroidal tumors

Keywords: thyroid gland; nodal tumors; fine-needle aspiration biopsy; pathomorphological investigation.

Abstract

Objective. Comparative estimation of diagnostic informativity of a fine-needle aspiration biopsy (FNAB) and pathohistological investigation of nodal thyroidal tumors.

Маterials and methods. Retrospective analysis of the FNAB and the thyroidal pathohistology results was conducted in 171 patients before and after thyroidectomy, performed for nodal thyroidal tumors.

Results. In accordance to the FNAB results a benign thyroidal affection was revealed in 131 (76.6%) patients and a malignant one - in 12 (7%). The method sensitivity has constituted 83.3%, and specificity - 98,5%. In 28 (16.4%) patients the FNAB results were uncertain. In 4 (14.3%) of 28 patients while further pathohistological investigation doing, a malignant affection of a thyroid gland was revealed (follicular cancer - in 1, papillary - in 1, follicular form of papillary cancer - in 1, Hurthle-cellular and papillary cancer - in 1). In 24 (85.7%) of 28 patients a benign thyroidal affection was revealed. In this group the FNAB sensitivity have constituted 65-99%, specificity - 98.5%. As a result of pathohistological investigation a benign thyroidal affection in 153 (89.5%) of 171 patients and malignant - in 18 (10.5%) were revealed.

Conclusion. In preoperative diagnosis of nodal thyroidal tumors the uncertain FNAB results rate in preoperative diagnosis of nodal thyroid tumors, in accordance to our data, have constituted 16.4%, what restricts possibilities of this method in verification of malignant thyroidal affections. That is why the operation must not be indicated, basing on the FNAB data only, and molecular-genetic markers ought to be analyzed in this group of patients.

Author Biographies

A. F. Hummatov, Аzerbaijan Medical University, Baku

Hummatov Azer Farachim- ph.dr, laboratory assistant
Department of Surgical Diseases No. 1
Azerbaijan Medical University.
azer_h_30@mail.ru
+994514063006
http://orcid.org/0000-0002-0046-0256

S. A. Aliev, Аzerbaijan Medical University, Baku

Aliev Saday Agalar - doctor of medical sciences, professor
aliyevaemil_85@mail.ru
+994514063006
http://orcid.org/0000-0002-3974-0781

A. N. Abbasoc, Аzerbaijan Medical University, Baku

Abbasoc Abbas Huseyn - candidate of Medical Sciences, dosent
abbasov@gmail.com
http://orcid.org/0000-0002-4901-6404 Abbas Abbasov

A. K. Ismaylov, Аzerbaijan Medical University, Baku

Ismayilov Araz Kamran - resident
Department of General Surgery
Azerbaijan Medical University.
ismayilov-a@mail.ru
http://orcid.org/0000-0001-6623-1598

M. R. Huseynova, Аzerbaijan Medical University, Baku

Huseynova Mehriban Rafael - Resident
Department of Surgical Diseases No. 1
Azerbaijan Medical University
mehribanhuseynova9@gmail.com
http://orcid.org/0000-0002-4040-5868 Mehriban Huseynova

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Published
2018-07-26
Section
General Problems of Surgery