Principles of differential diagnosis of purulent-necrotic processes of diabetic foot and sepsis

Keywords: diabetic foot syndrome; sepsis; cytokines; purulent-necrotic processes

Abstract

Objective. To assess a diagnostic validity of early markers of inflammatory process in differential diagnosis of purulent-necrotic processes of diabetic foot and development of sepsis.

Маterials and methods. There were examined 989 patients, suffering complicated  diabetic foot syndrome (DFS), of them in 97 (9.8%) the disease course was complicated by sepsis.

Results. Complicated by sepsis DFS may be differentiated in accordance to the changes in dynamics of contents of cytokines IL-1β, IL-6, IL-10, systemic cytokine TNF-α, аs well as С-reactive protein (CRP) and procalcitonin (PCT) in the blood serum.

Conclusion. Determination of the cytokines status, the content of CRP and PCT is diagnostically valuable while accomplishing of differential diagnosis for purulent-necrotic processes of diabetic foot and development of sepsis.

Author Biographies

S. D. Shapoval, Іnstitute of Sepsis of Zaporizhzhya Medical Academy of Postgraduate Education

Shapoval S. D. MD, PhD, DSci, Professor,

First Pro-rector

Zaporizhzhia Medical Academy of Post-Graduate Education

BoulevardWinter 20, Zaporoizhzhia, Ukraine 69096,

279-02-45,

shapoval.s.d@gmail.com 

ORSID ID – 0000-0001-8516-9494.

O. V. Trybushnyi, Іnstitute of Sepsis of Zaporizhzhya Medical Academy of Postgraduate Education

Tribushnyi O. V., MD, PhD, Associate Professor,

Deсan of Surgical Faculty

Zaporizhzhia Medical Academy of Post-Graduate Education

BoulevardWinter 20, Zaporoizhzhia, Ukraine 69096, tel.279-05-27,

tribushnoy.o.v@gmail.com,

ORCID ID 0000-0002-9298-2624

I. L. Savon, Іnstitute of Sepsis of Zaporizhzhya Medical Academy of Postgraduate Education

Savon I. L., MD, PhD, DSci, Associate Professor,

Head of the Department of Outpatient, Purulent-septic Surgery and Ultrasonography,

Zaporizhzhia Medical Academy of Post-Graduate Education

Boulevard Winter 20, Zaporoizhzhia, Ukraine 69096,

konsilium@ukr.net  

ORCID ID 0000-0001-8038-3731

L. Yu. Slobodchenko, Іnstitute of Sepsis of Zaporizhzhya Medical Academy of Postgraduate Education

Slobodchenko L.Yu. post-graduate student

Department of Outpatient, Purulent-Septic Surgery and Ultrasonography,

Zaporizhzhia Medical Academy of Post-Graduate Education

Boulevard Winter 20, Zaporoizhzhia, Ukraine 69096,

konsilium@ukr.net  

ORCID ID 0000-0002-2640-4244

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Published
2018-08-30
How to Cite
Shapoval, S. D., Trybushnyi, O. V., Savon, I. L., & Slobodchenko, L. Y. (2018). Principles of differential diagnosis of purulent-necrotic processes of diabetic foot and sepsis. Klinicheskaia Khirurgiia, 85(8), 30-32. https://doi.org/10.26779/2522-1396.2018.08.30
Section
General Problems of Surgery