Dynamics of the energy-structural activity in the inhalation anesthesia

Keywords: energy-structural interrelationship; inhalation anesthesia; metabolism; consumption of oxygen; neuroglial protein; neuronspecific enolase

Abstract

Objective. To improve the treatment results for patients, using the energy-protective trend in realizing of perioperative procuring of inhalation anesthesia with sevofluran.

Маterials and methods. Audit of the energy-structural activity while the inhalation anesthesia, using sevofluran, was conducted in patients, suffering acute abdominal pathology. In a comparison group of patients a conventional protocol was used, and in the main one – the organ-protective technologies. Clinical indices of danger, security, cardiac reserve, microcirculation–mitochondrial insufficiency (ММН), the blood concentration of a neuroglial protein (S100) and neurospecific enolase (NSE) were detected.

Results. The inhalation anesthesia, using sevofluran, disorders the energy-structural interrelationship in the body cellular mass (BCM). The energy-protective technologies lower the affection degree, what was witnessed by the blood concentration of S100 and NSE.

Conclusion. Application of the energy-protective technologies in accordance to categories of the energy-structural activity in BCM permits to improve the results of treatment in the patients, suffering an acute abdominal pathology and to personify the anesthesiological care. Close correlational connection between early signs of structural microtraumas of cerebral cells with the energy-structural changes in the patients’ BCM was revealed and proved.

Author Biographies

O. N. Boitsova, Zaporozhye State Medical University

Boitsova Olesya Nikolaevna, Assistant

Department of Medicine of Catastrophes, Military Medicine, Anesthesiology and Intensive Care. Zaporizhzhia State Medical University, .

69035, g. Zaporizhzhia, Mayakovsky avenue 26 

Tel.: (061) 224-63-91 

E-mail: Oboitsova1@gmail.com

https://orcid.org/0000-0002-4170-5635

L. M. Smirnova, Shalimov National Institute of Surgery and Transplantology, Kyiv

Smirnova Larysa Mykhaylivna, Doctor of Medicine. Chief Scientist

Shalimov National Institute of Surgery and Transplantology, Kyiv.

03087, g. Kiev, Нeroes of Sevastopolia, 30.. Tel.: 497-13-74.

E-mail: SMLM@ua.fm

https://orcid.org/0000-0003-2697-5458

G. A. Shifrin, Zaporozhye State Medical University

Shifrin Gregory Arkadyevich.  Doctor of Medicine, Professor.

Department of Medicine of Catastrophes, Military Medicine, Anesthesiology and Intensive Care. Zaporizhzhia State Medical University.

69035, g. Zaporizhzhia, Mayakovsky avenue 26 

Tel.: (061) 224-64-69

E-mail: G_Shifrin@i.ua 

 https://orcid.org/0000-0003-0017-0993

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Published
2018-08-30
How to Cite
Boitsova, O. N., Smirnova, L. M., & Shifrin, G. A. (2018). Dynamics of the energy-structural activity in the inhalation anesthesia. Klinicheskaia Khirurgiia, 85(8), 72-76. https://doi.org/10.26779/2522-1396.2018.08.72
Section
General Problems of Surgery