Impact of complex application of sorbilact and L-аrginin on separate indices of the endogenous intoxication syndrome of a purulent-septic genesis


Keywords: syndrome, syndrome of endogenous intoxication; sorbilact; L-аrginin

Abstract

Objective. To establish the impact of combined application of sorbilact and L-аrginin on renal detoxicating function and the indices of the endogenous intoxication syndrome (EIS) in a period of unstable compensation of toxicosis (on the seventh day of observation).

Маterials and methods. There was investigated the impact of administration of sorbilact and L-аrginin on a separate indices of the EIS of a purulent-septic genesis in patients of four Groups: Group I (control) - 31 patients with systemic inflammatory response syndrome (SIRS), Group II - 16 patients with EIS, to whom a standard therapy was conducted, Group III - 13 patients with EIS, to whom sorbilact was administered on a standard therapy base, Group IV - 10 patients with EIS, in whom a standard treatment was added by sorbilact with L-аrginin.

Results. On the seventh day of the investigation the middle mass molecules (MMM) excretion in patients with  EIS have constituted (7,5 ± 0,28) conventional units/min, what was by 77% higher, than in the patients of the control Group, but concentration of MMM in the blood serum have persisted in 2,1 times higher and their clearance hardly achieved a lower border of  a corresponding index in patients of the control Group, thus the EIS compensation have appeared unstable.

Conclusion. Application of complex, consisting of sorbilact and L-аrginin, activates a detoxication function of kidneys and reduces the endogenous intoxication severity of a purulent-septic genesis.

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Author Biographies


N. O. Maksymchuk, Bukovyna State Medical University, Chernivtsi

Maksymchuk N. O., postgraduate

Department of Anesthesiology and Resuscitation,

Bukovinian State Medical University, Chernivtsi, Ukraine.

Phone +380995614512

Е-mail: macksnat@gmail.com

http://orcid.org/0000-0002-8641-5455


V. M. Konovchuk, Bukovyna State Medical University, Chernivtsi

Konovchuk V. M., MD, PhD, Professor,

Head of the Department of Anesthesiology and Resuscitation

Bukovinian State Medical University, Chernivtsi, Ukraine.

Е-mail: konovchuk.viktor@bsmu.edu.ua

http://orcid.org/0000-0003-2231-4185

Published
2018-10-29
How to Cite
Maksymchuk, N. O., & Konovchuk, V. M. (2018). Impact of complex application of sorbilact and L-аrginin on separate indices of the endogenous intoxication syndrome of a purulent-septic genesis. Klinicheskaia Khirurgiia, 85(10), 53-56. https://doi.org/10.26779/2522-1396.2018.10.53
Section
General Problems of Surgery