Impact of complex application of sorbilact and L-аrginin on separate indices of the endogenous intoxication syndrome of a purulent-septic genesis

Keywords: syndrome, syndrome of endogenous intoxication; sorbilact; L-аrginin


Objective. To establish the impact of combined application of sorbilact and L-аrginin on renal detoxicating function and the indices of the endogenous intoxication syndrome (EIS) in a period of unstable compensation of toxicosis (on the seventh day of observation).

Маterials and methods. There was investigated the impact of administration of sorbilact and L-аrginin on a separate indices of the EIS of a purulent-septic genesis in patients of four Groups: Group I (control) - 31 patients with systemic inflammatory response syndrome (SIRS), Group II - 16 patients with EIS, to whom a standard therapy was conducted, Group III - 13 patients with EIS, to whom sorbilact was administered on a standard therapy base, Group IV - 10 patients with EIS, in whom a standard treatment was added by sorbilact with L-аrginin.

Results. On the seventh day of the investigation the middle mass molecules (MMM) excretion in patients with  EIS have constituted (7,5 ± 0,28) conventional units/min, what was by 77% higher, than in the patients of the control Group, but concentration of MMM in the blood serum have persisted in 2,1 times higher and their clearance hardly achieved a lower border of  a corresponding index in patients of the control Group, thus the EIS compensation have appeared unstable.

Conclusion. Application of complex, consisting of sorbilact and L-аrginin, activates a detoxication function of kidneys and reduces the endogenous intoxication severity of a purulent-septic genesis.


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Author Biographies

N. O. Maksymchuk, Bukovyna State Medical University, Chernivtsi

Maksymchuk N. O., postgraduate

Department of Anesthesiology and Resuscitation,

Bukovinian State Medical University, Chernivtsi, Ukraine.

Phone +380995614512


V. M. Konovchuk, Bukovyna State Medical University, Chernivtsi

Konovchuk V. M., MD, PhD, Professor,

Head of the Department of Anesthesiology and Resuscitation

Bukovinian State Medical University, Chernivtsi, Ukraine.


How to Cite
Maksymchuk, N. O., & Konovchuk, V. M. (2018). Impact of complex application of sorbilact and L-аrginin on separate indices of the endogenous intoxication syndrome of a purulent-septic genesis. Klinicheskaia Khirurgiia, 85(10), 53-56.
General Problems of Surgery