Impact of complex application of sorbilact and L-аrginin on separate indices of the endogenous intoxication syndrome of a purulent-septic genesis
Objective. To establish the impact of combined application of sorbilact and L-аrginin on renal detoxicating function and the indices of the endogenous intoxication syndrome (EIS) in a period of unstable compensation of toxicosis (on the seventh day of observation).
Маterials and methods. There was investigated the impact of administration of sorbilact and L-аrginin on a separate indices of the EIS of a purulent-septic genesis in patients of four Groups: Group I (control) - 31 patients with systemic inflammatory response syndrome (SIRS), Group II - 16 patients with EIS, to whom a standard therapy was conducted, Group III - 13 patients with EIS, to whom sorbilact was administered on a standard therapy base, Group IV - 10 patients with EIS, in whom a standard treatment was added by sorbilact with L-аrginin.
Results. On the seventh day of the investigation the middle mass molecules (MMM) excretion in patients with EIS have constituted (7,5 ± 0,28) conventional units/min, what was by 77% higher, than in the patients of the control Group, but concentration of MMM in the blood serum have persisted in 2,1 times higher and their clearance hardly achieved a lower border of a corresponding index in patients of the control Group, thus the EIS compensation have appeared unstable.
Conclusion. Application of complex, consisting of sorbilact and L-аrginin, activates a detoxication function of kidneys and reduces the endogenous intoxication severity of a purulent-septic genesis.
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