Investigation of immediate and late results of complex treatment in patients, suffering locally-spread mammary gland cancer, using systemic and endolymphatic neoadjuvant polychemotherapy

Keywords: locally-spread mammary gland cancer; complex therapy; endolymphatic polychemotherapy; systemic polychemotherapy

Abstract

Objective. To compare the immediate and late results of treatment in patients, suffering locally-spread mammary gland cancer (LSMGC), using various methods of administration of preparations for polychemotherapy (PCHTH).

Materials and methods. The investigation was conducted, basing on selective analysis of medical cards of 112 stationary patients, suffering LSMGC Stage T4A-DN0-3M0, who obtained complex antitumoral treatment on the base of the Donetsk Regional Antitumoral Centre and the University Clinic of the Odessa National medical University in 2000 - 2017 yrs. Into the comparison group 65 (58%) women-patients were included, suffering inoperable forms of a LSMGC, to whom a systemic polychemotherapy (SPCHTH) was conducted in a neoadjuvant regime. Into the investigation group 47 (42%) women-patients were included with inoperable forms of a LCMGC, to whom, as a neoadjuvant course, endolymphatic PCHTH (EPCHTH), was conducted.

Result. In the aspect of indices of a three- and a five-year survival a statistically significant difference between the groups investigated was absent. Immediate results of the women-patients, to whom a neoadjuvant ELPCHTH was conducted, have shown no statistically significant difference with those, treated, using SPCHTH.

Conclusion. Immediate and late results of complex therapy for a LSMGC in unfavorable prognosis of tumoral growth with conduction of ELPCHTH in a neoadjuvant regime and performance of radical operative intervention are better, comparing with the treatment result in accordance to similar scheme, but with conduction of SPCHTH on a preoperative stage, without statistical significance.

Author Biographies

Yu. V. Dumansky, Donetsk National Medical University, Lyman

Dumanskiy Yuriy

Department of the oncology and radiology

Donetsk medical university

84404 Donetsk region, Liman, Privokzalnaia street 27

+380992234015

oncologdopc@gmail.com

ORCID: http://orcid.org/0000-0003-2293-0869

O. V. Bondar, Odessa National Medical University, Centre of reconstructive and Restoration Medicine «University Clinic», Odessa

Bondar Oleksandr

Department of surgery # 4 with oncology

Odesa state medical university

Heard of the mammology department

University clinic of Odesa medical university

65009 Odessa region, Odessa, 8 Tinista str.

+380660658689

ovbondar0708@gmail.com

ORCID: http://orcid.org/0000-0001-8746-1878

O. I. Tkachenko, Odessa National Medical University

Tkachenko Oleksandr

Department of surgery # 4 with oncology

Odesa state medical university

65009 Odessa region, Odessa, 8 Tinista str.

+380503366933

doctortkachenko@i.ua

ORCID: http://orcid.org/0000-0001-7929-0220

E. A. Stolyarchuk, Centre of reconstructive and Restoration Medicine «University Clinic», Odessa

Stoliachuk Evhenii Resident of the surgical department

University clinic of Odesa medical university

65009 Odessa region, Odessa, 8 Tinista str.

+380939834719

engenes100@gmail.com

ORCID: http://orcid.org/0000-0003-0561-5357

V. Yu. Ermakov, Centre of reconstructive and Restoration Medicine «University Clinic», Odessa

Ermakov Vasilii Resident of the surgical department

University clinic of Odesa medical university

65009 Odessa region, Odessa, 8 Tinista str.

+380636228174

vacatrial1994@icloud.com

ORCID: http://orcid.org/0000-0003-4430-7146

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Published
2018-11-01
How to Cite
Dumansky, Y. V., Bondar, O. V., Tkachenko, O. I., Stolyarchuk, E. A., & Ermakov, V. Y. (2018). Investigation of immediate and late results of complex treatment in patients, suffering locally-spread mammary gland cancer, using systemic and endolymphatic neoadjuvant polychemotherapy. Klinicheskaia Khirurgiia, 85(11), 57-60. https://doi.org/10.26779/2522-1396.2018.11.57
Section
General Problems of Surgery