Estimation of efficacy for paracetamol application in perioperative anesthesia during endovideosurgical interventions on abdominal organs

Keywords: perioperative anesthesia; endovideosurgical interventions; dexketoprofen; paracetamol; cortisol


Objective. To estimate the efficacy of paracetamol application in perioperative anesthesia during endovideosurgical interventions (EVSI) on the abdominal cavity organs.

Materials and methods. There were examined 132 patients, in whom EVSI were performed under general anesthesia. In the Group I (main) (n=66) after induction narcosis intravenous infusion of 1000 mg of paracetamol was conducted. Of a Group II (control) (n=66) in 20 patients before the operation dexketoprofen in the 50 mg dose was injected intravenously. In postoperative period all the patients have obtained dexketoprofen intravenously in 50 mg dose in 6 - 8 h during three days.

Results. The level of cortisol in the blood in both Groups have raised, achieving maximal values on traumatic stage in EVSI: (453 ± 46) nmol/l - in Group I and (527 ± 43) nmol/l - in Group II (p < 0.05). Further it have lowered, remaining higher in the Group II (p < 0.05). Estimation of pain in accordance to visual-analogous scale in Group I, comparing with Group II, was lower in 6 h postoperatively on 2,1, in  12 h - on 1,4, in 24 h - by 1,6 points (p < 0.05).

Conclusion. Application of paracetamol in perioperative anesthesia is effective and has advantages over standard administration of dexketoprofen preoperatively.


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Author Biography

A. I. Denysenko, Scientific-Practical Centre of Prophylactic and Clinical Medicine, Kyiv

Denysenko Anatolii Ivanovych PhD,

main scientific collaborator

miniinvasive surgery department

Scientific-practical centre of preventive and clinical medicine

tel. +38-067-284-09-95; +38-050-569-63-93.


How to Cite
Denysenko, A. I. (2018). Estimation of efficacy for paracetamol application in perioperative anesthesia during endovideosurgical interventions on abdominal organs. Klinicheskaia Khirurgiia, 85(11), 65-67.
General Problems of Surgery