Peculiarities of secondary biopsy in patients with prostatic intraepithelial neoplasia
Objective. To determine the optimal quantity of the biopsy columns in cases, suspicious for prostatic gland cancer (PGC) and optimal terms for conduction of secondary biopsy of prostatic gland (PG) in patients with prostatic intraepithelial neoplasia (PIN).
Materials methods. Results of a three-year follow-up of 166 patients with PIN, in whom the diagnosis was established, using pancreatic biopsy and taking of 6 - 18 columns of the tissue.
Results. Of 166 patients with PIN in 58 (34.9%) PGC was revealed. The least (23.1%) rate of the PGC revealing was in patients, in whom a 12-points primary biopsy was performed. The biggest (62.5%) rate of the PGC revealing was in patients, in whom a 6-point primary biopsy was conducted. After a 6-point biopsy a majority cases of the PGC observation were registered during a first year. After a 12-point biopsy with the probes taken from more than 12 points a PGC was revealed most frequently on the third year. In patients after the biopsy taken with obtaining of 8 - 10 columns of the PG tissue the PGC was revealed during a second year.
Conclusion. Optimal quantity of the tissue biopsy probes was 12 columns, optimal terms for secondary biopsy constitute 6 - 12 mo after performance of a 6-point biopsy and 24 - 36 mo - after the 12-pointed and more procedure.
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