Interrelationship of the endothelial dysfunction markers in endothelial dysfunction in purulent cholangitis in patients, suffering chronic hepatitis and without chronic hepatitis on background of obturation jaundice


Keywords: markers of endothelial dysfunction; purulent cholangitis; antiviral therapy

Abstract

Objective. Studying of interrelationship of the endothelial dysfunction markers in endothelial dysfunction in purulent cholangitis in patients, suffering chronic hepatitis and without chronic hepatitis on background of obturation jaundice, revealing of its early transition into hepatic cirrhosis and optimization of the treatment tactics in pre-  and postoperative periods with estimation of the laboratory tests indices investigated.

Маterials and methods. The investigation was conducted in 15 patients with purulent cholangitis, of them in 9 patients was chronic hepatitis, in 6 patients chronic hepatitis was absent. Of 9 patients, suffering chronic hepatitis, in 4 antiviral therapy was not conducted, while in 5 - conducted.

Results. Immediate results of the diagnosis-treatment investigation conducted witnesses about similar signs of endothelial dysfunction in purulent cholangitis in patients, suffering chronic hepatitis and without chronic hepatitis.

In all the patients, suffering purulent cholangitis, decompression of biliary ducts was accomplished, the obturation causes were eliminated, detoxication therapy was conducted.

In accordance to correlation analysis of indices of the endothelium functional state in patients, suffering chronic hepatitis, who obtained antiviral therapy, improvement was noted on the 10th day, in 1 mo it was more significant, than in patients, who did not obtained antiviral therapy.

In 6 patients, suffering purulent cholangitis without chronic hepatitis, a timely surgical, desintoxication treatment with ozonotherapy have resulted in improvement of the endothelial functional state indices on the 10th day, in 1 mo they have approached to norm.

Conclusion. A timely revealing of endothelial dysfunction in purulent cholangitis in patients, suffering chronic hepatitis and without chronic hepatitis, promotes an early prognostication of its transition into stage of hepatic cirrhosis and correct selection of the treatment tactics  before and after the operation. Here may be concluded, that in purulent cholangitis in patients, suffering chronic hepatitis, it is expedient to conduct antiviral therapy before and after the operation.

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Author Biographies


A. A. Mammedov, Тоpchibashev Scientific Centre of Surgery, Baku, Аzerbaijani Republic

Mammеdov A.A. – MD, DSci (Med), Professor, 

Scientific Director of the Department of Hepato-biliary and Pancreatic Surgery

Scientific Center of Surgery named after Acad. M.A.Topchubashov,

AZ  1122 , 196 Sharifazade str. Baku Azerbaijan

mob.: 050 220 55 35

mammedov@gmvil.com   

 https://orcid.org/0000-0001-6352-1290 


E. A. Alieva, Тоpchibashev Scientific Centre of Surgery, Baku, Аzerbaijani Republic

Alieva E.A. – MD, DSci (Med)

Chief Researcher of the Department of Hepato-biliary and Pancreatic Surgery

Scientific Center of Surgery named after Acad. M.A.Topchubashov,

AZ 1122 , 196 Sharifazade str. Baku Azerbaijan

 mob.: 050 345 93 95

agaali.aliev@mail.ru

https://orcid.org/0000-0002-7626-9490 


N. M. Hasanov, Тоpchibashev Scientific Centre of Surgery, Baku, Аzerbaijani Republic

Hasanov N.M., MD, PhD,

Head of the Department of Hepato-biliary and Pancreatic Surgery

Scientific Center of Surgery named after Acad. M.A.Topchubashov,

AZ 1122 , 196 Sharifazade str. Baku Azerbaijan

mob.:050 311 36 89

n.namiq@rambler.ru

https://orcid.org/0000-0002-1175-863X


F. S. Idrisov, Тоpchibashev Scientific Centre of Surgery, Baku, Аzerbaijani Republic

Idrisov F.S. MD, PhD, Senior Researcher

Department of Hepato-biliary and Pancreatic Surgery

Scientific Center of Surgery named after Acad. M.A.Topchubashov,

AZ 1122, 196 Sharifazade str. Baku Azerbaijan

mob.: 050 513 64 08

idrisovfarac@gmail.com     

https://orcid.org/0000-0002-8848-9212


E. A. Iskenderov, Тоpchibashev Scientific Centre of Surgery, Baku, Аzerbaijani Republic

Iskenderov E.A– MD, DSci (Med),

 Leading Researcher of the Department of Hepato-biliary and Pancreatic Surgery

Scientific Center of Surgery named after Acad. M.A.Topchubashov,

AZ  1122 , 196 Sharifazade str.  Baku Azerbaijan

mob.: 050 335 40 84

eiskenderov@yahoo.com   

https://orcid.org/0000-0002-4015-3605 

Published
2018-12-28
How to Cite
Mammedov, A. A., Alieva, E. A., Hasanov, N. M., Idrisov, F. S., & Iskenderov, E. A. (2018). Interrelationship of the endothelial dysfunction markers in endothelial dysfunction in purulent cholangitis in patients, suffering chronic hepatitis and without chronic hepatitis on background of obturation jaundice. Klinicheskaia Khirurgiia, 85(12), 9-12. https://doi.org/10.26779/2522-1396.2018.12.09
Section
General Problems of Surgery