Morphological features of reparative process in trophic venous lower-extremity ulcers using autologous platelet-rich plasma


Keywords: trophic ulcer, chronic venous insufficiency, autologous platelet-rich plasma, podoplanin, CD 31

Abstract

Objective. Aim to study process of tissue reparation in zone of trophic ulcers of venous origin.

Materials and methods. A total of 57 patients with lower-extremity trophic ulcers was included during their treatment using autologous platelet-rich plasma at the Department of Surgery of Sumy Hospital for Military Veterans of Second World War.

Results. On day 20, the main group had decrease of ulcer defect in 45.8% out of the initial surface. In group of comparison this measurement was 31.4%, 1.4-fold less than in the main one.  

Conclusions. Using autologous platelet-rich plasma advances regeneration in zone of ulcer and shortens the period of epithelium formation in 2.3-fold.

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Author Biographies


I. D. Duzhiy, Sumy State University

Igor Duzhiy, MD, DM, prof.,

head of general surgery, radiation medicine and phthisiology department.

Sumy State University, Ukraine.

8 Troitska str., 4000, Sumy, Ukraine

+380679549638

Email: gensurgery@med.sumdu.edu.ua

orcid.org/0000-0002-4995-0096


V. M. Popadynets, Sumy State University

Vasyl Popadynets, MD, PhD student.

Department of general surgery, radiation medicine and phthisiology.

Sumy State University, Ukraine.

+380664183310

8 Troitska str., 4000, Sumy, Ukraine

Email: vpopadinets@gmail.com

orcid.org/0000-0002-9727-0909


A. M. Romaniuk, Sumy State University

Anatolii Romaniuk, MD, DM, prof.,

head of pathology department.

Sumy State University, Ukraine.

+380956006435

31 Pryvokzalna str., 4000, Sumy, Ukraine

Email: pathomorph@gmail.com

orcid.org/0000-0003-2560-1382


A. S. Nikolaienko, Sumy State University

Andrii Nikolaienko, MD, PhD student.

Department of general surgery, radiation medicine and phthisiology.

Sumy State University, Ukraine.

+380997349741

8 Troitska str., 4000, Sumy, Ukraine

Email: nikolaenko_as@ukr.net

https://orcid.org/0000-0002-6766-144X 

O. V. Kravets, Sumy State University

Oleksandr Kravets, MD, PhD.

Assistant Professor of general surgery, radiation medicine and phthisiology.

Sumy State University, Ukraine.

+380501746786

8 Troitska str., 4000, Sumy, Ukraine

 Email: kravets.oleksandr@ukr.net

orcid.org/0000-0003-3394-6671


V. V. Sikora, Sumy State University

Vladyslav Sikora, MD, PhD student.

Department of pathology.

Sumy State University, Ukraine.

+380507276193

31 Pryvokzalna str., 4000, Sumy, Ukraine

 Email: v.sikora@med.sumdu.edu.ua

orcid.org/0000-0002-4147-6879


M. S. Lyndin, Sumy State University

Mykola Lуndіn, MD, PhD.

Assistant Professor of pathology department.

Sumy State University, Ukraine.

+380977155524

31 Pryvokzalna str., 4000, Sumy, Ukraine

Email: n.lyndin@med.sumdu.edu.ua

orcid.org/0000-0003-4385-3903

Published
2018-12-28
How to Cite
Duzhiy, I. D., Popadynets, V. M., Romaniuk, A. M., Nikolaienko, A. S., Kravets, O. V., Sikora, V. V., & Lyndin, M. S. (2018). Morphological features of reparative process in trophic venous lower-extremity ulcers using autologous platelet-rich plasma. Klinicheskaia Khirurgiia, 85(12), 42-45. https://doi.org/10.26779/2522-1396.2018.12.42
Section
General Problems of Surgery