Determination of optimal term of conduction of neoadjuvant targeted therapy in patients with localized reno-cellular carcinoma


Keywords: reno-cellular carcinoma; neoadjuvant targeted therapy

Abstract

Objective. To determine an optimal term of the neoadjuvant targeted therapy (NATTH) conduction in treatment of patients, suffering localized reno-cellular carcinoma (LRCC).

Маterials and methods. Into the randomized prospective investigation 24 patients, suffering clear-celled LRCC (Т1а-2bN0M0), who were divided into two Groups, were included: the 1-st Group - 12 patients, to whom two blocks of NATTH (peroral pazopanib 800 mg daily during 28 days) were conducted; and the 2-nd Group - 12 patients, to whom four blocks of NATTH were conducted.

Results. Stabilization of the process (in accordance to RECIST 1.1 scale) was registered in 9 (75%) patients of the 1-st Group and in 8 (67%) - of the 2-nd Group, while a partial answer - in 3 (25%) and 4 (33%) patients, accordingly (χ2= 0.2; р = 0.65). The medians of tumoral regression in the 1-st and 2-nd Groups were comparable: 18 [2; 27] and 17 [2; 34]%, accordingly. Statistical difference between the adverse effects rate in accordance to the CTC AE scale Degrees 1 - 4, performance of nephrectomy, іntra- and postoperative complications and duration of the hospital stay in the Groups compared was absent (р > 0.05).

Conclusion. An optimal term for the NATTH conduction in patients, suffering LRCC, is application of two blocks. More durable NATTH leads to enhancement of cost of the treatment without further regress of LRCC, what do not impact the choice of the surgical treatment tactics.

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Author Biographies


O. A. Voylenko, National Cancer Institute, Kyiv

Voylenko Oleg A. - MD, PhD (Med),  

Senior Researcher of Department of Plastic and Reconstructive Oncological Urology,

National Cancer Institute,

33/43 Lomonosova Str., 03022, Kyiv, Ukraine

+38 050 501 19 03

voilenko@rambler.ru

https://orcid.org/0000-0003-3781-3622


M. V. Pikul, National Cancer Institute, Kyiv

Pikul Maksym V. - MD,

Urologist of Department of Plastic and Reconstructive Oncological Urology,

National Cancer Institute,

33/43 Lomonosova Str., 03022, Kyiv, Ukraine

+38 093205 06 96

urogenetics@gmail.com

https://orcid.org/0000-0003-1590-235X


O. E. Stakhovskiy, National Cancer Institute, Kyiv

Stakhovskyi Oleksandr E. - MD, PhD (Med),

Senior Researcher of Department of Plastic and Reconstructive Oncological Urology,

National Cancer Institute,

33/43 Lomonosova Str., 03022, Kyiv, Ukraine

+38 050 381 72 17

stakhovsky9@gmail.com

https://orcid.org/0000-0002-7528-551X


O. A. Kononenko, National Cancer Institute, Kyiv

Kononenko Oleksii A. - MD, PhD (Med),

Researcher of Department of Plastic and Reconstructive Oncological Urology,

National Cancer Institute,

33/43 Lomonosova Str., 03022, Kyiv, Ukraine

+38 097 269 32 35

kononenko_ol@ukr.net

https://orcid.org/0000-0002-7081-5964


S. L. Semko, National Cancer Institute, Kyiv

Semko Sofiya L. - MD,

Urologist of Department of Plastic and Reconstructive Oncological Urology,

National Cancer Institute,

33/43 Lomonosova Str., 03022, Kyiv, Ukraine

+38 063 252 65 36

semkosofiya@gmail.com

https://orcid.org/0000-0002-1657-5752


Yu. V. Vitruk, National Cancer Institute, Kyiv

Vitruk Iurii V. - MD, PhD (Med),

Senior Researcher of Department of Plastic and Reconstructive Oncological Urology,

National Cancer Institute,

33/43 Lomonosova Str., 03022, Kyiv, Ukraine

+38 050 673 20 82

uvitruk@ukr.net

https://orcid.org/0000-0003-3466-0552


E. O. Stakhovskiy, National Cancer Institute, Kyiv

Stakhovsky Eduard O. - MD, Doctor of Science (Med), Professor,

Head of Department of Plastic and Reconstructive Oncological Urology,

National Cancer Institute,

33/43 Lomonosova Str., 03022, Kyiv, Ukraine

+38 067 236 51 75

estakhovsky@yahoo.com

https://orcid.org/0000-0001-5677-8768

Published
2019-01-30
How to Cite
Voylenko, O. A., Pikul, M. V., Stakhovskiy, O. E., Kononenko, O. A., Semko, S. L., Vitruk, Y. V., & Stakhovskiy, E. O. (2019). Determination of optimal term of conduction of neoadjuvant targeted therapy in patients with localized reno-cellular carcinoma. Klinicheskaia Khirurgiia, 85(1), 56-60. https://doi.org/10.26779/2522-1396.2019.01.56
Section
General Problems of Surgery

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