Intra-abdominal infections: the blood serum interleukin-10 in perioperative period

Keywords: intra-abdominal infections; interleukin-10; the blood serum; perioperative period

Abstract

Objective. To assess the blood serum IL-10 concentration in patients with intra-abdominal infections.

Materials and methods. Clinical specimens were obtained from 56 patients, suffering intra-abdominal infections of various origin: 24 patients - with postoperative abscesses, 12 - with primary intra-abdominal abscesses, and 20 - with diffuse or local peritoneal collection at the day before surgical intervention, on 2nd-3rd day and on 5th-7th day after it.

Results. There was no trustworthy difference established between the blood serum IL-10 concentrations in patients with different origin of intra-abdominal infections in perioperative period. The significant difference was established, while comparing concentrations of IL-10 in the blood serum in patients with intra-abdominal infections before and on the days 2-3 and 5-7 postoperatively, and in healthy persons.

Conclusion. Concentration of the blood serum IL-10 ≥ 6.78 pg/mL in patients with different origin of intra-abdominal infections has significant prognostic significance: sensitivity (92.86%) and specificity (80.65%). Further studies, targeting a specific causative agent of nosocomial infection and the cytokine response, are needed.

Author Biographies

A. S. Riga, Kharkiv National Medical University

Riga Artem S., post-graduate student
Department of Surgery № 1,
Kharkiv National Medical University,
61022, Kharkiv, Nauki ave, 4;
tel: 0577077380;
е-mail: yaartyom888@gmail.com
orchid.org/0000-0003-2130-5260

V. V. Boyko, Kharkiv National Medical University

Boyko Valeriy V., DSci(Med), Professor,
Head of the Department of Surgery № 1,
Kharkiv National Medical University,
61022, Kharkiv, Nauki ave, 4;
tel: 0577077380;
е-mail: doctorvaleriy88@ukr.net
orcid.org/0000-0003-0702-637X

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Published
2019-02-27
How to Cite
Riga, A. S., & Boyko, V. V. (2019). Intra-abdominal infections: the blood serum interleukin-10 in perioperative period. Klinicheskaia Khirurgiia, 86(2), 28-32. https://doi.org/10.26779/2522-1396.2019.02.28
Section
General Problems of Surgery