Intra-abdominal infections: the blood serum interleukin-10 in perioperative period
Objective. To assess the blood serum IL-10 concentration in patients with intra-abdominal infections.
Materials and methods. Clinical specimens were obtained from 56 patients, suffering intra-abdominal infections of various origin: 24 patients - with postoperative abscesses, 12 - with primary intra-abdominal abscesses, and 20 - with diffuse or local peritoneal collection at the day before surgical intervention, on 2nd-3rd day and on 5th-7th day after it.
Results. There was no trustworthy difference established between the blood serum IL-10 concentrations in patients with different origin of intra-abdominal infections in perioperative period. The significant difference was established, while comparing concentrations of IL-10 in the blood serum in patients with intra-abdominal infections before and on the days 2-3 and 5-7 postoperatively, and in healthy persons.
Conclusion. Concentration of the blood serum IL-10 ≥ 6.78 pg/mL in patients with different origin of intra-abdominal infections has significant prognostic significance: sensitivity (92.86%) and specificity (80.65%). Further studies, targeting a specific causative agent of nosocomial infection and the cytokine response, are needed.
2. Sartelli M, Catena F, Abu-Zidan FM, Ansaloni L, Biffl WL, Boermeester MA, et al. Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference. World J Emerg Surg. 2017 May 4;12:22 https://doi.org/10.1186/s13017-017-0132-7.
3. Shyam Gelot, Engi Nakha. Intra-abdominal Infecyions in Adults. US Pharm.2016:41(4): HS5-HS12
4. Sartelli M, Abu-Zidan FM, Catena F, Griffiths EA, Di Saverio S, Coimbra et al. Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: a prospective multicentre study (WISS Study). World J Emerg Surg. 2015 Dec 16;10:61. https://doi.org/10.1186/s13017-015-0055-0.
5. Kumar V. May T cells and their immunometabolism: A novel way to understanding sepsis immunopathogenesis and future therapeutics. Eur J Cell Biol. 2018 Aug; 97(6):379-392. https://doi.org/10.1016/j.ejcb.2018.05.001.
6. Koerner P, · Busemann A,· Traeger T, · Kessler W, · Cziupka K, · Diedrich S, et al. Postoperative Immune Suppression in Visceral Surgery: Characterisation of an Intestinal Mouse Model. Eur Surg Res. 2011;47(4):260-6. https://doi.org/10.1159/000333391.
7. Jie Wu, Aini Xie, Wenhao Chen. Cytokine regulation of immune tolerance Burns & Trauma. 2014 January; 2(1): 11-7. https://doi.org/10.4103/2321-3868.124771.
8. Braat H, Rottiers P, Hommes DW, Huyghebaert N, Remaut E, Remon JP, et al. A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn’s disease. Clin Gastroenterol Hepatol. 2006 Jun;4(6):754-9. https://doi.org/10.1016/j.cgh.2006.03.028.
9. Vallejo M, Cuesta DP, Florez LE, Correa A, Llanos CE, Isaza B, et al. Clinical and microbiological characteristics of complicated intra-abdominal infection in Colombia: a multicenter study. Rev Chilena Infectol. 2016 Jun; 33(3):261-7. https://doi.org/10.4067/S0716-10182016000300002.
10. Kato M, Honda I, Suzuki H, Murakami M, Matsukawa S, Hashimoto Y. Interleukin-10 production during and after upper abdominal surgery. J Clin Anesth. 1998 May; 10(3):184-8. PMID: 9603586.
11. Stein K, Lysson M, Schumak B, Vilz T, Specht S, Heesemann J, Roers A, Kalff JC, Wehner S. Leukocyte-Derived Interleukin-10 Aggravates Postoperative Ileus. Front Immunol. 2018 Nov 13; 9:2599. https://doi.org/10.3389/fimmu.2018.02599.
12. Cloe L. Sparreboom, Zhouqiao Wu, Adem Dereci, Geesien S. A. Boersema, Anand G. Menon, Jiafu Ji, Gert-Jan Kleinrensink, Johan F. Lange. Cytokines as Early Markers of Colorectal Anastomotic Leakage: A Systematic Review and Meta-Analysis. Gastroenterol Res Pract. 2016; 2016: 3786418. https://doi.org/10.1155/2016/3786418
13. Maruna P, Gurlich R, Frasko R, Chachkhiani I, Marunova M, Owen K, Peskova M. Cytokines and soluble cytokine receptors in the perioperative period. Sb Lek. 2002; 103(2):273-82. PMID: 12688152. [In Czech].
14. Surbatovic M, Popovic N, Vojvodic D, Milosevic I, Acimovic G, Stojicic M, et al. Cytokine profile in severe gram-positive and gram-negative abdominal sepsis. Sci Rep. 2015 Jun 16;5:11355. doi: 10.1038/srep11355. https://doi.org/10.1038/srep11355.
15. Ferreira JFG, Rezende-Neto JB, Pinto-SilvaRA, de Souza JG, de Macedo FariasL, de CarvalhoMARet al. Microbiota Evaluation and Extracellular Cytokine Profile in Patients Affected with Intraabdominal Infection. Br J Med Med Res. 2016; 15(4):1-14. https://doi.org/10.9734/BJMMR/2016/25281
This work is licensed under a Creative Commons Attribution 4.0 International License.