Ultrastructural adaptation of mucosa of orthotopic ileal bladder in the late period dynamics in experiment
Abstract
Objective. To estimate the changes in ultrastructure of mucosa in artificially created orthotopic bladder in 12 mo after іleocystoplasty in experiment on a dwarf pigs.
Маterials and methods. Еxperimental investigations were conducted on 18 female dwarf pigs ageing 4 – 15 mo, in whom cystectomy was performed with artificially created orthotopic bladder, using ileocystoplasty.
Results. In mucosal ultrastructure of the artificially created bladder under durable influence of urine the columnar cells in epithelial layer gradually transform into cells of another type, which are structurally close to the bladder epithelium, adjusted for performance of its full-fledged function. Own mucous plate have had destructive changes predominantly in cellular elements, in some portions fibrous structures prevailed over cellular.
Conclusion. Changes in ultrastructure of mucosa of artificially created bladder in 12 mo after іleocystoplasty witness about its complete transformation and adaptation with elements of evolution and adaptation to new conditions of functioning.
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