Ultrastructural adaptation of mucosa of orthotopic ileal bladder in the late period dynamics in experiment
Abstract
Objective. To estimate the changes in ultrastructure of mucosa in artificially created orthotopic bladder in 12 mo after іleocystoplasty in experiment on a dwarf pigs.
Маterials and methods. Еxperimental investigations were conducted on 18 female dwarf pigs ageing 4 – 15 mo, in whom cystectomy was performed with artificially created orthotopic bladder, using ileocystoplasty.
Results. In mucosal ultrastructure of the artificially created bladder under durable influence of urine the columnar cells in epithelial layer gradually transform into cells of another type, which are structurally close to the bladder epithelium, adjusted for performance of its full-fledged function. Own mucous plate have had destructive changes predominantly in cellular elements, in some portions fibrous structures prevailed over cellular.
Conclusion. Changes in ultrastructure of mucosa of artificially created bladder in 12 mo after іleocystoplasty witness about its complete transformation and adaptation with elements of evolution and adaptation to new conditions of functioning.
References
2. Wang K, Yamataka A, Morioka A, Lane GJ, Iwashita K, Miyano T. Complications after sigmoidocolocystoplasty: review of 100 cases at one institution. J Pediatr Surg. 1999 Nov;34(11):1672-7. https://doi.org/10.1016/S0022-3468(99)90642-5.
3. Jin L, Wang M, Yang F, Niu Y, Xing N. Surgical techniques for facilitating laparoscopic intracorporeal orthotopic neobladder: initial experience. Int Braz J Urol. 2018 Nov-Dec;44(6):1156-65. doi: 10.1590/S1677-5538.IBJU.2017.0505.
4. Abdelrhman MA, Seddek AM, Bakr HA, Elnesr KA. Full-thickness hysterocystoplasty for management of a large bladder defect: experimental study in goats. J Vet Med Sci. 2013 Jan 75(6):767-71. https://doi.org/10.1292/jvms.12-0298.
5. Dapena L, Dapena I, Regadera J, Gaspar MJ, Gonzalez-Peramato P. Histerocystoplasty: a novel surgical procedure in the rat. J Surg Res. 2012 Jun 1;175(1):157-62. https://doi.org/10.1016/j.jss.2011.03.002.
6. Fishman IJ, Flores FN, Scott FB, Spjut HJ, Morrow B. Use of fresh placental membranes for bladder reconstruction. J Urol. 1987 Nov;138(5):1291-4. https://doi.org/10.1016/S0022-5347(17)43586-5.
7. Kambic H, Kay R, Chen JF, Matsushita M, Harasaki H, Zilber S. Biodegradable pericardial implants for bladder augmentation: a 2.5-year study in dogs. J Urol. 1992 Aug;148(2 Pt 2):539-43.https://doi.org/10.1016/S0022-5347(17)36649-1.
8. Sloff M, de Vries R, Geutjes P, IntHout J, Ritskes-Hoitinga M, Oosterwijk E. Tissue Engineering in Animal Models for Urinary Diversion: A Systematic Review. PLoS One. 2014 Jun 25;9(6):e98734. https://doi.org/10.1371/journal.pone.0098734.
9. Alberti C. Whyever bladder tissue engineering clinical applications still remain unusual even though many intriguing technological advances have been reached? G Chir. 2016 Jan-Feb; 37(1): 6–12. https://doi.org/10.11138/gchir/2016.37.1.006.
10. Cerruto MA, D'Elia C, Siracusano S, Gedeshi X, Mariotto A, Iafrate M, Niero M et all. Systematic review and meta-analysis of non RCT's on health related quality of life after radical cystectomy using validated questionnaires: Better results with orthotopic neobladder versus ileal conduit. Eur J Surg Oncol. 2016 Mar;42(3):343-60. https://doi.org/10.1016/j.ejso.2015.10.001.
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