Perspectives of application of the fibrin matrix, enhanced by thrombocytes, in neuroregenerative surgery


Perspectives of application of the fibrin matrix, enhanced by thrombocytes, in neuroregenerative surgery


1. Edgar L, McNamara K, Wong T, Tamburrini R, Katari R, Orlando G. Hete rogeneity of Scaffold Biomaterials in Tissue Engineering. Materials (Basel). 2016 May 3;9(5). pii: E332.

2. Bhattarai DP, Aguilar LE, Park CH, Kim CS. A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering.Membranes (Basel). 2018 Aug 14; 8(3). pii: E62.

3. Beumer GJ, van Blitterswijk CA, Ponec M. Degradative behaviour of polymeric matrices in (sub)dermal and muscle tissue of the rat: a quantitative study. Biomaterials. 1994 Jun;15(7):551-9. PMID: 7918908

4. Alessandri M, Lizzo G, Gualandi C, Mangano C, Giuliani A, Focarete ML, et al. Influence of biological matrix and artificial electrospun scaffolds on proliferation, differentiation and trophic factor synthesis of rat embryonic stem cells. Matrix Biol. 2014 Jan;33:68-76.

5. Kim SH, Song JE, Lee D, Khang G. Development of poly (lactide-co-glycolide) scaffold-impregnated small intestinal submucosa with pores that stimulate extracellular matrix production in disc regeneration. J Tissue Eng Regen Med. 2014 Apr;8(4):279-90.

6. Mosher CZ, Spalazzi JP, Lu HH. Stratified scaffold design for engineering composite tissues. Methods. 2015 Aug;84:99-102.

7. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):e37-44.

8. Piccin A, Di Pierro AM, Canzian L, Primerano M, Corvetta D, Negri G, et al. Platelet gel: a new therapeutic tool with great potential. Blood Transfus. 2017 Jul;15(4):333-40. doi: 10.2450/2016.0038-16. Epub 2016 Jul 25.

9.Schar MO, Diaz-Romero J, Kohl S, Zumstein MA, Nesic D. Platelet-rich concentrates differentially release growth factors and induce cell migration in vitro. Clin Orthop Relat Res. 2015 May;473(5):1635-43.

10. Bahmanpour S, Ghasemi M, Sadeghi-Naini M, Kashani IR. Effects of Platelet-Rich Plasma & Platelet-Rich Fibrin with and without Stromal Cell-Derived Factor-1 on Repairing Full-Thickness Cartilage Defects in Knees of Rabbits. Iran J Med Sci. 2016 Nov;41(6):507-17. PMID: 27853331

11. Isobe K, Watanebe T, Kawabata H, Kitamura Y, Okudera T, Okudera H, et al. Mechanical and degradation properties of advanced platelet-rich fibrin (A-PRF), concentrated growth factors (CGF), and platelet-poor plasma-derived fibrin (PPTF). Int J Implant Dent. 2017 Dec;3(1):17.

12. Xie X, Zhang C, Tuan RS. Biology of platelet-rich plasma and its clinical application in cartilage repair. Arthritis Res Ther. 2014 Feb 25;16(1):204.

13. Wu CL, Lee SS, Tsai CH, Lu KH, Zhao JH, Chang YC. Platelet-rich fibrin increases cell attachment, proliferation and collagen-related protein expression of human osteoblasts. Aust Dent J. 2012 Jun;57(2):207-12.

14. Wang X, Zhang Y, Choukroun J, Ghanaati S, Miron RJ. Behavior of Gingival Fibroblasts on Titanium Implant Surfaces in Combination with either Injectable-PRF or PRP. Int J Mol Sci. 2017 Feb 4;18(2). pii: E331

15. Sanchez M, Anitua E, Delgado D, Sanchez P, Prado R, Orive G, et al. Platelet-rich plasma, a source of autologous growth factors and biomimetic scaffold for peripheral nerve regeneration. Expert Opin Biol Ther. 2017 Feb;17(2):197-212.

16. Roh YH, Kim W, Park KU, Oh JH. Cytokine-release kinetics of platelet-rich plasma according to various activation protocols. Bone Joint Res. 2016 Feb;5(2):37-45.

17. Mussano F, Genova T, Munaron L, Petrillo S, Erovigni F,Carossa S. Cytokine, chemokine, and growth factor profile of platelet-rich plasma. Platelets. 2016 Jul;27(5):467-71.

18. Huang EJ, Reichardt LF. Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem. 2003 Mar 27;72:609-42.

19. Galvez-Contreras AY, Quinones-Hinojosa A, Gonzalez-Perez O. The role of EGFR and ErbB family related proteins in the oligodendrocyte specification in germinal niches of the adult mammalian brain. Front Cell Neurosci. 2013 Dec 17;7:258.

20. Woodbury ME, Ikezu T. Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration. J Neuroimmune Pharmacol. 2014 Mar;9(2):92-101.

21. Nieto-Estevez V, Defterali C, Vicario-Abejon C. IGF-I: A Key Growth Factor that Regulates Neurogenesis and Synaptogenesis from Embryonic to Adult Stages of the Brain. Front Neurosci. 2016 Feb 23;10:52.

22. Cacci E, Salani M, Anastasi S, Perroteau I, Poiana G, Biagioni S,et al. Hepatocyte growth factor stimulates cell motility in cultures of the striatal progenitor cells ST14A. J Neurosci Res. 2003 Dec 1;74(5):760-8.

23.Funa K, Sasahara M. The roles of PDGF in development and during neurogenesis in the normal and diseased nervous system. J Neuroimmune Pharmacol. 2014 Mar;9(2):168-81.

24. Schwab JM, Beschorner R, Nguyen TD, Meyermann R, Schluesener HJ. Differential cellular accumulation of connective tissue growth factor defines a subset of reactive astrocytes, invading fibroblasts, and endothelial cells following central nervous system injury in rats and humans. J Neurotrauma. 2001 Apr;18(4):377-88.]

25. Sun FY, Guo X. Molecular and cellular mechanisms of neuroprotection by vascular endothelial growth factor. J Neurosci Res. 2005 Jan 1-15;79(1-2):180-4.

26. Choe Y, Pleasure SJ, Mira H. Control of Adult Neurogenesis by Short-Range Morphogenic-Signaling Molecules. Cold Spring Harb Perspect Biol. 2015 Dec 4;8(3):a018887.

27. Keefe KM, Sheikh IS, Smith GM. Targeting Neurotrophins to Specific Populations of Neurons: NGF, BDNF, and NT-3 and Their Relevance for Treatment of Spinal Cord Injury. Int J Mol Sci. 2017 Mar 3;18(3). pii: E548.]

28. Kim JY, Jeon WJ, Kim DH, Rhyu IJ, Kim YH, Youn I, et al. An inside-out vein graft filled with platelet-rich plasma for repair of a short sciatic nerve defect in rats. Neural Regen Res. 2014;9:1351–1357.

29. Sabongi RG, De Rizzo LALM, Fernandes M, Valente SG, Gomes dos Santos JB, Faloppa F, et al. Nerve regeneration: is there an alternative to nervous graft? J Reconstr Microsurg. 2014 Nov;30(9):607-16.

30. Lichtenfels M, Colome L, Sebben AD, Braga-Silva J. Effect of Platelet Rich Plasma and Platelet Rich Fibrin on sciatic nerve regeneration in a rat model. Microsurgery. 2013 Jul;33(5):383-90.

31. Giannessi E, Coli A, Stornelli MR, Miragliotta V, Pirone A, Lenzi C, et al. An autologously generated platelet-rich plasma suturable membrane may enhance peripheral nerve regeneration after neurorraphy in an acute injury model of sciatic nerve neurotmesis. J Reconstr Microsurg. 2014 Nov;30(9):617-26.

32. Ye F, Li H, Qiao G, Chen F, Tao H, Ji A, et al. Platelet-rich plasma gel in combination with Schwann cells for repair of sciatic nerve injury. Neural Regen Res. 2012 Oct 15;7(29):2286-92.

33. Sariguney Y, Yavuzer R, Elmas C, Yenicesu I, Bolay H, Atabay K. Effect of platelet-rich plasma on peripheral nerve regeneration. J Reconstr Microsurg. 2008 Apr;24(3):159-67.

34. Bertolini GRF, Kakihata CMM, Peretti AL, Bernardino GR, Karvat J, Silva JLC, et al. Effects of the platelet-rich fibrin associated with physical exercise in a model of median nerve compression. Motriz, Rio Claro. 2017;23(4): e1017100.

35. Chen NF, Sung CS, Wen ZH, Chen CH, Feng CW, Hung HC, et al. Therapeutic Effect of Platelet-Rich Plasma in Rat Spinal Cord Injuries. Front Neurosci. 2018 Apr 23;12:252.

36. Peden CS, Burger C, Muzyczka N, Mandel RJ Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain. J Virol. 2004 Jun;78(12):6344-59.

37. Marshall E. Gene therapy. Second child in French trial is found to have leukemia. Science. 2003 Jan 17;299(5605):320.

38. Kuffler DP, Reyes O, Sosa IJ, Santiago-Figueroa J. Neurological recovery across a 12-cm-long ulnar nerve gap repaired 3.25 years post trauma: case report. Neurosurgery. 2011 Dec;69(6):E1321-6.

39. Malahias MA, Johnson EO, Babis GC, Nikolaou VS. Single injection of platelet-rich plasma as a novel treatment of carpal tunnel syndrome. Neural Regen Res. 2015 Nov;10(11):1856-9.

40. Scala M, Mereu P, Spagnolo F, Massa M, Barla A, Mosci S, et al. The use of platelet-rich plasma gel in patients with mixed tumour undergoing superficial parotidectomy: a randomized study. In Vivo. 2014 Jan-Feb;28(1):121-4. PMID: 24425846.

41. Khojasteh A, Hosseinpour S, Nazeman P, Dehghan MM. The effect of a platelet-rich fibrin conduit on neurosensory recovery followinginferior alveolar nerve lateralization: a preliminary clinical study. Int J Oral Maxillofac Surg. 2016 Oct;45(10):1303-8

42. Mendonca JJ, Juiz-Lopez P. Regenerative facial reconstruction of terminal stage osteoradionecrosis and other advanced craniofacial diseases with adult cultured stem and progenitor cells.Plast Reconstr Surg. 2010 Nov;126(5):1699-709.

Author Biographies

V. I. Tsymbalyuk, Institute of Neurosurgery named after А. P. Romodanov NAMS of Ukraine, Kyiv

Tsymbalyuk Vitaly Ivanovich, MD, DSci(Med), Professor,
Chief Researcher of the Department of Reconstructive and Functional Neurosurgery
Romodanov Neurosurgery Institute
32, Platona Mayborody St., Kiev, 04050 Ukraine.
Phone: +380 44 483 95 73.

I. G. Vasylieva, Institute of Neurosurgery named after А. P. Romodanov NAMS of Ukraine, Kyiv

Vasylieva Iryna Georgievna, PhD(Biol)
Head of Department of Neurobiochemistry
Romodanov Neurosurgery Institute
32, Platona Mayborody St., Kiev, 04050 Ukraine.
Phone: +380 44 483 95 73

How to Cite
Tsymbalyuk, V. I., & Vasylieva, I. G. (2019). Perspectives of application of the fibrin matrix, enhanced by thrombocytes, in neuroregenerative surgery. Klinicheskaia Khirurgiia, 86(2), 74-78.