Late results of treatment of patients, suffering ischemic cardiomyopathy, with application of stem cells of umbilical blood
Objective. Comparative analysis of late results of the stem cells transplantation, obtained from umbilical blood (SCTUB) and surgical revascularization in patients, suffering an ischemic cardiomyopathy (ІCMP).
Маterials and methods. Late results of teatment in 113 patients, suffering chronic cardiac insufficiency on background of ІCMP, were analyzed. In 38 (33.6%) patients the isolated coronary shunting was performed, in 35 (31.0%) – stenting of coronary arteries, in 20 (17.7%) – surgical revascularization was added by SCTUB. Separate group of the patients, consisted of 20 (17.7%) persons, in whom independent conservative therapy was accomplished. The follow–up duration have constituted 12 mo.
Results. In 6 mo after SCTUB in the patients, suffering ІCMP the left ventricular ejection fraction have raised from 24.8 tо 33.3% (р < 0.05), while the level of N–terminal pro brain natriuretic peptidе (proBNP) have lowered by 51.6% (from 499.0 tо 257.5 pg/ ml). The effect achieved have persisted through 12 mo of observation. Holter day monitoring of electrocardiogram, conducted in 3, 6 and 12 mo after SCTUB, did not show trustworthy enhancement of risk for occurrence of fatal arrhythmia.
Conclusion. Application of SCTUB in complex of treatment in patients, suffering ІCMP, favorably impacts prognosis for the cardio–vascular mortality, reduces the cardiac insufficiency signs, improves the patients’ quality of life and myocardium’s contractile function trustworthily.
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