Estimation of prognostic criteria in the psoriasis course for further correction of treatment in patients postoperatively
Objective. To investigate immunohistochemical changes in the skin of patients, suffering psoriasis, for prognostication of possible postoperative exacerbation of cutaneous psoriatic process.
Маterials and methods. There was conducted preoperative immunohistochemical investigation of the biopsy material, obtained from sites of cutaneous psoriatic rashes and іntact skin in patients, suffering psoriasis. Besides this, for comparison of the immunohistochemical results the cutaneous biopsy material of anterior abdominal wall was, obtained in 5 practically healthy persons of a certain age after performance of hernioplasty. For estimation of character and spreading of local cellular reactions in the skin of the patients, suffering psoriasis, immunohistochemical procedures were applied for determination of expression of the immune inflammation markers.
Results. Results of preoperative investigation of changes in immunohistochemical expression of proinflammatory biological markers in the skin of psoriatic patients, with further analysis of impact of such stressful factor, as operative intervention, have witnessed its influence on the cutaneous psoriasis course.
Conclusion. There was proved, that one of mechanisms of the inflammatory reactions exacerbation in patients, suffering psoriasis, constitutes activation of immunocompetent cells, including those, which are acting via the Toll–receptors, what makes possible to improve the tactics of treatment in patients during postoperative period.
2. Takeda K, Akira S. Toll-receptors in innate immunity. Int Immunol. 2005 Jan; 17(1):1-14. https://doi.org/10.1093/intimm/dxh186.
3. Janeway CA Jr, Medzhitov R. Innate immune recognition. Annu Rev Immunol. 2002;20:197- 201. https://doi.org/10.1146/annurev.immunol.20.083001.084359.
4. Kopp EB, Medzhitov R. The Toll-receptor family and control of innate immunity. Curr Opit Immunol. 1999 Feb; 11(1):13-28. PMID: 10047546.
5. Zhang D, Zhang G, Hayden MS, Greenblatt MB, Bussey C, Flavell RA, et al. A toll-like receptor that prevents infection by uropathogenic bacteria. Science. 2004 Mar 5;303(5663):1522-6. https://doi.org/10.1126/science.1094351.
6. Mclnturff R, Modlin JK, Kim J. The role of toll-like receptors in the pathogenesis and treatment of dermatological disease. J Invest Derm. 2005;125(1):1-8. https://doi.org/10.1111/j.0022-202X.2004.23459.x.
7. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001 Aug; 2(8): 675-80. https://doi.org/10.1038/90609.
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