Estimation of prognostic criteria in the psoriasis course for further correction of treatment in patients postoperatively


Keywords: psoriasis; immunohistochemical changes in the skin; Toll–like receptors; оperative intervention

Abstract

Objective. To investigate immunohistochemical changes in the skin of patients, suffering psoriasis, for prognostication of possible postoperative exacerbation of cutaneous psoriatic process.

Маterials and methods. There was conducted preoperative immunohistochemical investigation of the biopsy material, obtained from sites of cutaneous psoriatic rashes and іntact skin in patients, suffering psoriasis. Besides this, for comparison of the immunohistochemical results the cutaneous biopsy material of anterior abdominal wall was, obtained in 5 practically healthy persons of a certain age after performance of hernioplasty. For estimation of character and spreading of local cellular reactions in the skin of the patients, suffering psoriasis, immunohistochemical procedures were applied for determination of expression of the immune inflammation markers.

Results. Results of preoperative investigation of changes in immunohistochemical expression of proinflammatory biological markers in the skin of psoriatic patients, with further analysis of impact of such stressful factor, as operative intervention, have witnessed its influence on the cutaneous psoriasis course.

Conclusion. There was proved, that one of mechanisms of the inflammatory reactions exacerbation in patients, suffering psoriasis, constitutes activation of immunocompetent cells, including those, which are acting via the Toll–receptors, what makes possible to improve the tactics of treatment in patients during postoperative period.

References

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Author Biographies


R. L. Stepanenko, Bogomolets National Medical University, Kyiv

Stepanenko Roman L. MD, DSci (Med),
Department of Dermatology and Veneteology,
Bogomolets National Medical University,
13 Shevchenko Bul, 01601, Kyiv, Ukraine
+380442873034
stepanenkorl@ukr.net
https://orcid.org/0000-0001-8423-0388


T. S. Konovalova, Bogomolets National Medical University, Kyiv

Konovalova Tatyana S.. MD, PhD (Med),
Department of Dermatology and Veneteology,
Bogomolets National Medical University,
13 Shevchenko Bul, 01601, Kyiv, Ukraine
+380442873034
konovalovats@ukr.net
https://orcid.org/0000-0002-8927-6542


V. I. Stepanenko, Bogomolets National Medical University, Kyiv

Stepanenko Viktor I. MD, DSci (Med), Professor
Head of Department of Dermatology and Veneteology,
Bogomolets National Medical University,
13 Shevchenko Bul, 01601, Kyiv, Ukraine
+380442873034
stepanenkovi_prof@ukr.net
https://orcid.org/0000-0003-4710-1151


V. M. Ivantsok, Bogomolets National Medical University, Kyiv

Ivantsok Volodymyr M. MD, PhD (Med)
Associate Professor Department of Sergery #4
Bogomolets National Medical University,
13 Shevchenko Bul, 01601, Kyiv, Ukraine
+380442551560
v.ivantsok@gmail.com
https://orcid.org/0000-0002-3933-3043

Published
2019-02-28
How to Cite
Stepanenko, R. L., Konovalova, T. S., Stepanenko, V. I., & Ivantsok, V. M. (2019). Estimation of prognostic criteria in the psoriasis course for further correction of treatment in patients postoperatively. Klinicheskaia Khirurgiia, 86(3), 65-70. https://doi.org/10.26779/2522-1396.2019.03.65
Section
General Problems of Surgery