Clinico-morphological characteristic of papillary thyroidal carcinomas in patients, born before and after of the Chornobyl AES disaster
Objective. To study the thyroidal papillary carcinomas rate with various characteristics, depending on the patients’ age, taking into account their birthdate - before and after disaster on Chornobyl AES.
Маterials and methods. Retrospective investigation concerning 4956 patients, оperated for papillary thyroidal carcinoma in 1995 - 2014 yrs.
Results. In the patients, ageing up to 18 years old, comparing with adult patients, and not dependent on their birthdate, most frequent tumors were 21 - 40 mm in size, categories N1ab and М1, with tumoral invasion into the capsule, іntra- or extrathyroidal invasion were observed. In children and adolescents, born after disaster, less often, than in children and adolescents, born before the disaster, multifocal carcinomas and carcinomas of category N1ab were observed.
Conclusion. Papillary carcinomas in children and adolescents, who were born before and after disaster on Chornobyl AES, are more aggressive, than papillary carcinomas in adult patients, but by their clinical characteristics are similar, excluding lesser rate of multifocal carcinomas and carcinomas of category N1ab.
2. Furukawa K, Preston D, Funamoto S, Yonehara S, Ito M, Tokuoka S, et al. Long-term trend of thyroid cancer risk among Japanese atomic-bomb survivors: 60 years after exposure. Int J Cancer 2013 Mar; 132(5):1222-6. doi: 10.1002/ijc.27749.
3. Gerasimov G, Figge D. Chernobyl: twenty years later. Klin Eksperim. Tireoidologija 2006;2(2):5-14. [In Russian].
4. Tronko M, Bogdanova T, Voskoboynyk, Zurnadzhy L, Shpak V, Gulak L. Radiation induced cancer: fundamental and applied aspects. Exp Oncol. 2010;32(3):200-4. PMID: 21403618.
5. LiVolsi V, Abrosimov A, Bogdanova T, Fadda G, Hunt J, Ito M. et al. The Chernobyl thyroid cancer experience: pathology. Clin Oncol (R Coll Radiol). 2011; 23(4): 261-7. doi: 10.1016/j.clon.2011.01.160.
6. Tronko M, Shpak V, Bogdanova T, Saenko V, Yamashita Sh. Epidemiology of thyroid cancer in Ukraine after Chernobyl. In: Thyroid cancer in Ukraine after Chernobyl: dosimetry, epidemiology, pathology, molecular biology. NASHIM: IN-TEX, Nagasaki, Japan. 2014;39-64.
7. Dal Maso L, Bosetti C, La Vecchia C, Franceschi S. Risk factors for thyroid cancer: an epidemiological review focused on nutritional factors. Cancer Causes Control. 2009;20(1):75-86. doi: 10.1007/s10552-008-9219-5.
8. Davies L, Welch H. Thyroid cancer survival in the United States: observational data from 1973 to 2005. Arch Otolaryngol Head Neck Surg. 2010;136(5):440-4. doi: 10.1001/archoto.2010.55.
9. Hampson S, Stephens D, Wasserman J. Young age is associated with increased rates of residual and recurrent paediatric differentiated thyroid carcinoma. Clin Endocrinol (Oxf). 2018;89(2):212-8. doi: 10.1111/cen.13720.
10. Palaniappan R, Krishnamurthy A, Rajaraman S, Kumar R. Management outcomes of pediatric and adolescent papillary thyroid cancers with a brief review of literature. Indian J Cancer. 2018;55(1):105-10. doi: 10.4103/ijc.IJC_486_17.
11. Azhar Y, Achmad D, Lukman K, Hilmanto D. Pediatric differentiated thyroid carcinoma risk factor for analysis for disease free survival. Indian J Med Paediatr Oncol. 2018;39(2):153-8. doi: 10.4103/ijmpo.ijmpo_70_17.
12. Zirilli G, Cannavo L, Vermiglio F, Violi M, Luca F, Wasniewska M. Differentiated thyroid carcinoma presentation may be more aggressive in children and adolescents than in young adults. Ital J Pediatr. 2018;44(1):13. doi: 10.1186/s13052-018-0455-3.
13. Guda B, Kovalenko A, Bolgov M, Taraschenko Yu, Mykhailenko N. Main prognostic factors for well differentiated thyroid cancer: Analis of combined patients treatment results during 20 years after surgery. Thyroid Disorders Ther. 2018;7(1):228. doi: 10.4172/2167-7948.1000228.
14. Bogdanova T, Saenko V, Brenner A, Zurnadzhy L, Rogounovitch T, Likhtarov I, et al. Comparative histopathologic analysis of ‘‘radiogenic’’ and ‘‘sporadic’’ papillary thyroid carcinoma: Patients born before and after the Chernobyl accident. Thyroid. 2018;28(7):880-90. doi: 10.1089/thy.2017.0594.
15. Tuttle R, Vaisman F, Tronko M. Clinical presentation and clinical outcomes in Chernobyl-related pediatric thyroid cancers: what do we know now? What can we expect in the future? Clin Oncol (R Coll Radiol). 2011;23(4):268-75. doi: 10.1016/j.clon.2011.01.178.
Copyright (c) 2019 Liga-Inform
This work is licensed under a Creative Commons Attribution 4.0 International License.