Integrative monitoring of systemic hemodynamics and the oxygen-transport status and the choice of the intensive therapy tactics in patients, suffering an ischemic cerebral insult

Abstract

Objective. To elaborate the intensive therapy tactic in patients, suffering ischemic cerebral insult (ICI) depending on changes in the systemic hemodynamics indices and the oxygen-transportation status.Маterials and methods. In 42 patients, suffering the ICI of middle severity, ageing 45 - 88 years old, the integrative monitoring of the neurological state severity, systemic hemodynamics indices and the oxygen-transportation status on background of targeted intensive therapy was conducted.

Results. In the patients, suffering initial hypoxemia, a hypokinetic heart index (HI) - (2,0±0,1) l×min^-1×m^-2 and the lowered systemic delivery of oxygen (DO₂) - (356±21) ml×min^-1×m^-2were revealed. Prophylactic oxygenation is needed if the value of the oxygen content in arterial blood (SаO₂) exceeds 95% and DO₂ is lesser than 520 ml×min^-1×m^-2. Aiming the achievement of eukinetic values of the HI, correction of vascular spasm and antihypertensive therapy was conducted, using alpha-adrenoblocking agent (urapydil) up to stabilization of the DO₂ indices on the level of 520-600 ml×min^-1×m^{-2. In} hyperoxidal state a hyperkinetic HI - (3.6±0.1) l×min^-1×m^-2 and a raised DO₂ - (699±14) ml×min^-1×m^-2 were revealed. Prophylactic oxygenation is not indicated if the value of the SаO₂ index exceeds 95% and DO₂ exceeds 600 ml×min^-1×m^-2. Aiming to achieve eukinetic values of HI it is mandatory to conduct antihypertensive therapy, using therapy with аlpha-beta-аdrenoblocking agent (labetalol).

Conclusion. Targeted intensive therapy, oriented towards balance with general oxygenation of the organism tissues, normalizes the oxygen-transport homeostasis in shortest terms, what impacts the results of treatment in patients, suffering ICI, immediately.