Application of a borate-containing glass for the treatment of trophic wounds in children, suffering myelodysplasia
Objective. To estimate the possibility of application of a borate-containing glass material while treating trophic wounds in children, suffering myelodysplasia.
Маterials and methods. The data, concerning 3 children, who, while their newborn time were operated on for a spinal cord hernias, are presented. All the children have had myelodysplastic disordered trophic wound of the lower extremities, causing severe course of the wounds or the bedsores healing. Bioactive borate-containing glass «Mirragen», manufactured in USA, was proposed by medical centre «Меdyvo» for treatment of trophic wounds in children.
Results. Application of bioactive borate-containing glass while treating trophic wounds in children, suffering myelodysplasia, was effective. Deep wounds during 8 weeks have had healed completely without complications, and a superficial wound—bedsore - during 5 weeks. The wounds have epithelized steadily, starting together from the bottom and periphery with velocity up to 12-15% of their square weekly. Negative general or local reaction towards a borate-containing glass in the patients was absent.
Conclusion. Тemporary biomaterial, structured by a carcass, made of a borate-containing glass, guarantees a necessary form establishment, needed for creation of a new tissues and promotion of rapid healing of the wounds. Application of a bioactive borate-containing glass constitutes a safe and efficient method of treatment for trophic wounds in children, suffering myelodysplasia.
Guo S, DiPietro LA. Factors Affecting Wound Healing. J Dent Res.2010;89(3): 219-9. doi: 10.1177/0022034509359125.
Nelson EA. Venous leg ulcers. BMJ Clin Evid. 2011;2011. pii: 1902. PMID: 22189344.
Elikbaev GM, Hachatrjan VA. Mielodisplazija u detej: osobennosti diagnostiki i kliniki. Nejrohirurgija i nevrologija Kazahstana. 2009;(1); 15-23. [In Russian].
Xie X, McGregor M, Dendukuri N. The clinical effectiveness of negative pressure wound therapy: a systematic review. J Wound Care. 2010;19(11):490-5. doi: 10.12968/jowc.2010.19.11.79697.
MO-SCI Online: Mo-Sci Corporation, Specialty Glass Manufacturere. [Internet]. Available from: https://store.mo-sci.com/collections/bioactive-glass.
Rahaman MN, Day DE, Bal BS, Fu Q, Jung SB, Bonewald LF, Tomsia AP. Bioactive glass in tissue engineering. Acta Biomater. 2011;7(6):2355-73. doi: 10.1016/j.actbio.2011.03.016.
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