Application of a borate-containing glass for the treatment of trophic wounds in children, suffering myelodysplasia

Keywords: bioactive borate-containing glass; poorly healing wounds; children


Objective. To estimate the possibility of application of a borate-containing glass material while treating trophic wounds in children, suffering myelodysplasia.

Маterials and methods. The data, concerning 3 children, who, while their newborn time were operated on for a spinal cord hernias, are presented. All the children have had myelodysplastic disordered trophic wound of the lower extremities, causing severe course of the wounds or the bedsores healing. Bioactive borate-containing glass «Mirragen», manufactured in USA, was proposed by medical centre «Меdyvo» for treatment of trophic wounds in children.

Results. Application of bioactive borate-containing glass while treating trophic wounds in children, suffering myelodysplasia, was effective. Deep wounds during 8 weeks have had healed completely without complications, and a superficial wound—bedsore - during 5 weeks. The wounds have epithelized steadily, starting together from the bottom and periphery with velocity up to 12-15% of their square weekly. Negative general or local reaction towards a borate-containing glass in the patients was absent.

Conclusion. Тemporary biomaterial, structured by a carcass, made of a borate-containing glass, guarantees a necessary form establishment, needed for creation of a new tissues and promotion of rapid healing of the wounds. Application of a bioactive borate-containing glass constitutes a safe and efficient method of treatment for trophic wounds in children, suffering myelodysplasia.

Author Biographies

М. G. Меlnychenko, Оdessa National Medical University

Melnychenko Maryna G. - PhD, Doctor of Medicine, Professor,
Professor of the Department of Pediatric Surgery
Odessa National Medical University (Odessa, Ukraine).
Contact Address: Olhyivska street 4, Odessa, Odesa region, 65000, Ukraine.
Phone: +380501976185

І. R. Dilanyan, Оdessa Regional Pediatric Clinical Hospital

Dilanian Iona R. - PhD, Assistant,
Deputy Chief Surgery Officer
Odessa Regional Clinical Pediatric Hospital
Contact Address: 64, Generala Petrova st, apt. 75, Odessa, Ukraine 65078
Phone: +380505052000

L. P. Маtviychuk, Меdical Centre «Меdyvo», Odessa

Head of the surgical purulent-septic department of the CU "OODKL".
Address: Odessa Regional Clinical Children's Hospital,
Odessa, Ak Vorobyova street, 3, 65031
Phone: + 380677598743

А. М. Кlymenko, Меdical Centre «Меdyvo», Odessa

Klymenko Aleksey N.
Head of Medyvo Medical Center
Contact Address:Ak.Korolova street, 102/3, Odessa, Odesa region, 65000, Ukraine
Phone: +380975298860


Guo S, DiPietro LA. Factors Affecting Wound Healing. J Dent Res.2010;89(3): 219-9. doi: 10.1177/0022034509359125.

Nelson EA. Venous leg ulcers. BMJ Clin Evid. 2011;2011. pii: 1902. PMID: 22189344.

Elikbaev GM, Hachatrjan VA. Mielodisplazija u detej: osobennosti diagnostiki i kliniki. Nejrohirurgija i nevrologija Kazahstana. 2009;(1); 15-23. [In Russian].

Xie X, McGregor M, Dendukuri N. The clinical effectiveness of negative pressure wound therapy: a systematic review. J Wound Care. 2010;19(11):490-5. doi: 10.12968/jowc.2010.19.11.79697.

MO-SCI Online: Mo-Sci Corporation, Specialty Glass Manufacturere. [Internet]. Available from:

Rahaman MN, Day DE, Bal BS, Fu Q, Jung SB, Bonewald LF, Tomsia AP. Bioactive glass in tissue engineering. Acta Biomater. 2011;7(6):2355-73. doi: 10.1016/j.actbio.2011.03.016.

How to Cite
МеlnychenkoМ. G., DilanyanІ. R., МаtviychukL. P., & КlymenkoА. М. (2019). Application of a borate-containing glass for the treatment of trophic wounds in children, suffering myelodysplasia. Klinicheskaia Khirurgiia, 86(6), 34-37.
General Problems of Surgery