Results of surgical treatment of patients, suffering differentiated thyroidal cancer in surgical clinic through 20 years

Keywords: papillary carcinomas; follicular carcinomas; tumoral characteristics; surgical treatment; prognosis; mortality.

Abstract

Objective. To study the rate of differentiated thyroid carcinomas, owing various characteristics and clinical indices of the disease course, basing on a twenty-year experience of the surgical clinic work in the Institute of Endocrinology and Metabolism named after V. P. Komisarenko NAMS of Ukraine.

Materials and methods. Retrospective investigation was conducted, including data about 5526 patients, operated for differentiated thyroidal cancer in 1995 - 2014 yrs.

Results. During 20 years the quantity of patients, suffering papillary carcinoma, operated in surgical clinic, have enhanced. Among them the rate of children, teenagers, men and the patients, suffering more aggressive tumors, have reduced. Clinical indices of the disease course, tactic of treatment and prognosis concerning these patients have improved essentially. The spreading, size, invasive and metastatic characteristic of follicular carcinoma through 20 years of observation did not changed essentially, but the rate of patients, suffering severe stages of the disease and those having the poorest prognosis raised. Simultaneously a mortality of patients, suffering follicular carcinomas, have lowered significantly due to the treatment optimization.

Conclusion. The analysis performed have witnessed the rate reduction of potentially radio-induced papillary carcinomas, what demands a certain revision and further improvement of the patient’s treatment protocols.

Author Biographies

B. B. Guda, V. P. Komisarenko Institute of Endocrinology and Metabolism, Kyiv

Guda Bogdan B., - PhD (Med), Senior Researcher
Department of surgery,
V.P. Komisarenko Institute of Endocrinology and Metabolism
69 Vyshgorodskaja Str., 04114, Kyiv, Ukraine
+38(050)5457078
bguda@ukr.net
https://orcid.org/0000-0002-9181-0697

A. E. Kovalenko, V. P. Komisarenko Institute of Endocrinology and Metabolism, Kyiv

Kovalenko Andrew E., - MD, PhD (Med), Professor,
Head of Department of surgery
V.P. Komisarenko Institute of Endocrinology and Metabolism
69 Vyshgorodskaja Str., 04114, Kyiv, Ukraine
+38(066)2983899
ae@kovalenko.co.ua
https://orcid.org/0000-0003-0326-6421

M. Yu. Bolgov, V. P. Komisarenko Institute of Endocrinology and Metabolism, Kyiv

Michail Bolgov, PHD Endocrine surgeon,
Department of endocrine surgery,
V.P. Komisarenko Institute of Endocrinology and Metabolism
69 Vyshgorodska Str., 04114 Kyiv, Ukraine
+38044) 430-36-94;
e-mail: mikebolgov@gmail.com
ORCID: https://orcid.org/0000-0002-9011-9982

M. V. Ostafiychuk , V. P. Komisarenko Institute of Endocrinology and Metabolism, Kyiv

Marian V. Ostafiychuk,
Department of Surgery Endocrin Glands
V.P. Komisarenko Institute of Endocrinology and Metabolism
69 Vyshgorodska Str., 04114 Kyiv, Ukraine
+38 (044) 254–12–66
E-mail: skorpionmaryan@gmail.com
ORCID: https://orcid.org/0000-0002-0446-051X

References

Bogdanova T, Zurnadzhy L, LiVolsi V, Williams D, Ito M, Nakashima M, et al. Thyroid cancer pathology in Ukraine after Chernobyl. In: Thyroid cancer in Ukraine after Chernobyl: dosimetry, epidemiology, pathology, molecular biology. Editors Tronko M, Bogdanova T, Saenko V, Thomas G, Likhtaterv I, Yamashita S. NASHIM: IN-TEX, Nagasaki, Japan; 2014. 65-108.

Tronko M, Brenner A, Bogdanova T, Shpak V, Oliynyk V, Cahoon E, et al. Thyroid neoplasia risk is increased nearly 30 years after the Chernobyl accident. Int J Cancer. 2017;141(8):1585-8. doi: 10.1002/ijc.30857.

Gerasimov G, Figge D. Chernobyl: twenty years later. Klin. Eksperim. Tireoidologija 2006;2(2):5-14. [In Russian].

Tronko M, Bogdanova T. Thyroid cancer in children of Ukraine (consequences of the Chernobyl disaster). Kyiv: Chernobylinform; 1998. 200 p. [In Russian].

Acquaviva G, Visani M, Repaci A, Rhoden K, de Biase D, Pession A, et al. Molecular pathology of thyroid tumours of follicular cells: a review of genetic alterations and their clinicopathological relevance. Histopathology. 2018;72:6-31. doi: 10.1111/his.13380.

Hampson S, Stephens D, Wasserman J. Young age is associated with increased rates of residual and recurrent paediatric differentiated thyroid carcinoma. Clin Endocrinol (Oxf). 2018;89(2):212-8. doi: 10.1111/cen.13720.

Palaniappan R, Krishnamurthy A, Rajaraman S, Kumar R. Management outcomes of pediatric and adolescent papillary thyroid cancers with a brief review of literature. Indian J Cancer. 2018;55(1):105-10. doi: 10.4103/ijc.IJC_486_17.

Zirilli G, Cannavò L, Vermiglio F, Violi M, Luca F, Wasniewska M. Differentiated thyroid carcinoma presentation may be more aggressive in children and adolescents than in young adults. Ital J Pediatr. 2018;44(1):13. doi: 10.1186/s13052-018-0455-3.

Guda B, Kovalenko A. Clinical and morphological characteristics of papillary thyroid carcinoma in patients born to or after Chernobyl accident. Klinichna khirurgiya. 2019;86(4):29-33. doi: 10.26779/2522-1396.2019.04.29 [In Ukrainian].

Published
2019-07-07
How to Cite
Guda, B. B., Kovalenko, A. E., Bolgov, M. Y., & Ostafiychuk , M. V. (2019). Results of surgical treatment of patients, suffering differentiated thyroidal cancer in surgical clinic through 20 years. Klinicheskaia Khirurgiia, 86(7), 57-62. https://doi.org/10.26779/2522-1396.2019.07.57
Section
General Problems of Surgery