Estimation of functional renal reserve after renal resection in patients with reno-cellular cancer in the groups of various age
Objective. To estimate a functional renal reserve (FRR) in patients on early stages of reno-cellular cancer (RCC) in various age groups and its changes in postoperative period.
Materials and methods. In the investigation 49 patients, suffering RCC Stages T1N0M0, G1 - G3, histological subtype of RCC - clear-cellular cancer, took part. In all the patients the signs of urinal syndrome were revealed and renal resection accomplished. Into the Group I 9 patients were included, ageing 25 - 43 yrs old, the average age have constituted (34 ± 2.3) yrs; and into the Group II - 17 patients, ageing 44-59 yrs old, the average age have constituted (50 ± 1.3) yrs old; into the Group III - 23 patients, ageing 60 - 74 yrs old, average age have constituted (67 ± 2.1) yrs. The glomerular filtration rate in all the patients have equaled or exceeded 90 ml/min/1.73 m2.
Results. In 1mo after conduction of surgical treatment an average value of FRR in patients of the Group I have constituted (13.60 ± 1.24)%, while in the Group II - (8.70 ± 0.21)%. In 12 mo after conduction of surgical treatment the average value of FRR have constituted (3.22 ± 1.16)%.
Conclusion. In the patients, suffering RCC and ageing 25 - 43 yrs old, FRR was preserved. Renal resection in patients of this age group do not lead to lowering of FRR during 12 mo of observation. In the patients, suffering RCC and ageing 44 - 59 yrs old FRR is preserved also. After renal resection in patients of this age group during 12 mo of observation the FRR lowering occurs. In the patients, suffering RCC and ageing 60 - 75 yrs old FRR is lowered. After renal resection the patients of this age group during 12 mo losses FRR.
Fedorenko ZP, Goulak LO, Michailovich YY, Ryjov AY, Sumkina OV. Cancer in Ukraine 2015 - 2016. Bulletin of National cancer registry of Ukraine. Kyiv; 2017. 86 p.
De Moor B, Vanwalleghem JF, Swennen Q, Stas KJ, Meijers BKI. Haemodynamic or metabolic stimulation tests to reveal the renal functional response: requiem or revival? Clin Kidney J. 2018;11(5):623-54. doi: 10.1093/ckj/sfy022.
Wildes TM, Maggiore RJ, Tew WP, Smith D, Sun CL, Cohen H, et al. Factors associated with falls in older adults with cancer: a validated model from the Cancer and Aging Research Group. Support Care Cancer. 2018;26(10):3563-3570. doi: 10.1007/s00520-018-4212-3.
Sene AP, Hunt L, McMahon RF, Carroll RN. Renal carcinoma in patients undergoing nephrectomy: analysis of survival and prognostic factors. Br J Urol. 1992;70(2):125-34. PMID:1393433.
Wadowski PP, Hülsmann M, Schörgenhofer C, Lang IM, Wurm R, Gremmel T, et al. Sublingual functional capillary rarefaction in chronic heart failure. Eur J Clin Invest. 2018 Feb;48(2). doi: 10.1111/eci.12869.
Russo P, Goetzl M, Simmons R, Katz J, Motzer R, Reuter V. Partial nephrectomy: the rationale for expanding the indications. Ann Surg Oncol. 2002;9(7):680-7. PMID:12167583.
Lee CT, Katz J, Shi W, Thaler HT, Reuter VE, Russo P. Surgical management of renal tumors 4 cm or less in a contemporary cohort. J Urol. 2000;163(3):730-6. PMID:10687966.
Leibovich BC, Blute M, Cheville JC, Lohse CM, Weaver AL, Zincke H. Nephron sparing surgery for appropriately selected renal cell carcinoma between 4 and 7 cm results in outcome similar to radical nephrectomy. J Urol. 2004;171(3):1066-70. doi:10.1097/01.ju.0000113274.40885.db.
Ebbing J, Menzel F, Frumento P, Miller K, Ralla B, Fuller TF, et al. Outcome of kidney function after ischaemic and zero-ischaemic laparoscopic and open nephron-sparing surgery for renal cell cancer. BMC Nephrol. 2019;20(1):40. doi: 10.1186/s12882-019-1215-3.
Barreto EF, Rule AD, Murad MH, Kashani KB, Lieske JC, Erwin PJ, et al. Prediction of the Renal Elimination of Drugs With Cystatin C vs Creatinine: A Systematic Review. Mayo Clin Proc. 2019;94(3):500-514. doi: 10.1016/j.mayocp.2018.08.002.
Hozhenko AI, Kravchuk AV, Sirman VM, Nikitenko OP, Romaniv LV. Functional renal reserve: physiological value of renal reserve and substantion of the method of its determination. Kydney. 2015;(4):7-11. doi: 10.22141/2307-12126.96.36.199.2015.74890.
Amiel C, Blanchet F, Friedlander G, Nitenberg A. The functional renal reserve. Nephrologie. 1991;12(2):55-61 PMID:1944756.
Bosch JP, Saccaggi A, Lauer A, Ronco C, Belledonne M, Glabman S. Renal functional reserve in humans. Effect of protein intake on glomerular filtration rate. Am J Med. 1983;75(6):943-50. PMID:6650549.
Isharwal S, Ye W, Wang A, Abraham J, Zabell J, Dong W, et al. Impact of Comorbidities on Functional Recovery from Partial Nephrectomy. J Urol. 2018;199(6):1433-9. doi: 10.1016/j.juro.2017.12.004. doi:10.1016/j.juro.2017.12.004.
Rashidi Khazaee P, Bagerzadeh J, Niazkhani Z, Pirnejad H. Predicting the Function of Transplanted Kidney in Long-term Care Processes: Application of a Hybrid Model. J Biomed Inform. 2019;91:103116. doi: 10.1016/j.jbi.2019.103116.
Han QX, Zhang D, Zhao YL, Liu L, Li J, Zhang F, et al. Analysis of chronic kidney disease staging with different estimated glomerular filtration rateequations in Chinese centenarians. Chin Med J (Engl). 2019;132(5):512-518. doi: 10.1097/CM9.0000000000000079.
Van Londen M, Kasper N, Hessels NR, Messchendorp AL, Bakker SJL, Sanders JS, et al. Renal functional reserve capacity before and after living kidney donation. Am J Physiol Renal Physiol. 2018;315(6):F1550-F1554. doi: 10.1152/ajprenal.00064.2018.
Palsson R, Waikar SS. Renal Functional Reserve Revisited. Adv Chronic Kidney Dis. 2018 May;25(3):e1-e8. doi: 10.1053/j.ackd.2018.03.001.
Mistretta FA, Mazzone E, Knipper S, Karakiewicz PI. Benefit of nephron sparing surgery translates into lower cancer specific mortality in patients with localized renal cell carcinoma. Send to Ann Transl Med. 2018;6 (Suppl 2):S104. doi: 10.21037/atm.2018.11.37.
Verhagen PCMS, Boevé ER. The European Association of Urology Guideline on Renal Cell Carcinoma (RCC) is Not Concise in its Recommendation to Perform Partial Nephrectomy in T1b RCC. Eur Urol. 2019;76(1):132-133. doi: 10.1016/j.eururo.2019.01.020.
Papkevich II, Begun IV, Kazharskaya LG Functional renal reserve in children cured from nephroblastoma. Nephrology. 2002;6(4):66-9. doi.org/10.24884/1561-6274-2002-6-4-66-69.
This work is licensed under a Creative Commons Attribution 4.0 International License.