The impact of partial obstruction of common biliary duct without hyperbilirubinemia on the liver
Objective. Experimental studying of hepatic morphological changes and the blood biochemical indices in partial obstruction of common biliary duct (POCBD) without hyperbilirubinemia.
Materials and methods. POCBD was simulated on 34 laboratory animals. The animals were excluded from the experiment on the 3, 7, 14, 21, 28-th and 35-th day. The content of bilirubin, albumin, the blood serum urea and activity of alanine aminotransferase (AlAT), aspartate aminotransferase (AsAT), alkaline phosphatase (APH) were measured. The common biliary duct diameter, hepatic volume and mass were measured, hepatic histology investigated, and morphometry was performed. Control group consisted of 17 experimental animals.
Results. In 14 (41.2%) experimental animals POCBD without hyperbilirubinemia was observed. Maximal morphological changes were noted on the 28 - 35th day: the hepatic mass enhancement by 31% and the hepatic volume - by 25.5%; increase of the number and dilatation of biliary ducts, increase of the sinusoidal cells quantity, of the hepatocytes square, presence of the Degree II in 4of 5 observations. The changes of biochemical indices were trustworthy on the 3 - 7-th day: the albumin content have lowered down to (21.6 ± 2.5) g/l, while a control index constitutes (26.7 ± 1.6) g/l. Activity of AlAT, AsAT, APH, the urea content during the experiment did not differ from the control values.
Conclusion. Despite a complete functional compensation, POCBD without hyperbilirubinemia leads to significant morphological changes in the live, in spite of complete functional compensation presence.
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