Morphologic characteristic of the lungs in the patients, suffering experimental peritonitis
Objective. To study and estimate the morphological changes in the lungs of laboratory animals with experimental acute extended peritonitis.
Materials and methods. In this investigation were applied on 32 white laboratory rats. An acute peritonitis was simulated, using injection of 0.5 ml of a 10% solution of the fecal suspension probed into abdominal cavity of laboratory animals. The observation terms were implemented on the first, third and the seventh day from the beginning of the peritonitis simulation. Pulmonary tissue was taken for histological investigation. The organ pieces obtained were fixated in 10% solution of neutral formalin and then colored using hematoxylin and eosin.
Results. Distelectasis, the sites of collapse and emphysematous dilation of alveoli, have had occurred during all observation period of the exudative-inflammatory vascular reaction. The bronchi wall have thickened predominantly due to cellular infiltrates, the bronchioles lumens were free of exudate and cellular elements.
Conclusion. The sites of collapsing and emphysematous dilation of alveoli were revealed during histological investigation of pulmonary tissues in experimental animals with simulated acute extended peritonitis, comparing with intact rats in the first day of the experiment. On the third day the majority of vessels have had wide lumens filled with the blood, and erythrodiapedesis occurred into perivascular compartments and into lumens of a separate alveoli. On the 7th day significant dilation of the veins and the arteries filling with the blood was noted.
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