The impact of early peroral feeding on concentration of the serum interleukin–6 in patients after pancreaticoduodenectomy

Keywords: interleukin-6; panreaticoduodenectomy; enteral feeding; peroral feeding.

Abstract

Objective. The impact of early peroral feeding on concentration of the serum interleukin-6 in patients after pancreaticoduodenectomy was analyzed.

Materials and methods. Results of pancreaticoduodenectomy in 39 patients, suffering the pancreatic head and periampullar zone tumors, was analyzed, in whom various methods of nutritive support were applied through period 2015 - 2017 yrs. With the aim of comparative analysis accomplishment of immunological reactivity the patients were divided into two groups: the first - 24 patients, to whom in postoperative period a combination of peroral and enteral feeding was conducted, and in the second - 15 patients, to whom peroral feeding was applied only. There were studied concentration of the serum interleukin-8 preoperatively and on the third postoperative day, as well as the levels of general protein and albumin on the first, third and 7th postoperative days.

Results. In the patients, to whom nutritive support was done in a combined way (through microjejunostomy and in a peroral way), the level of interleukin-6 was higher (p=0.05), than in the patients, who used a peroral feeding only postoperatively: mediana 76.2 [51.5; 96.4] and 63.4 [43.5; 65,7] pg/ml, accordingly (p=0.055). While application of various methods of feeding in the patients a trustworthy difference between middle levels of albumin and general protein in the blood on the first, third and 7th days after pancreaticoduodenectomy was not observed (p > 0.05) while application of different feeding methods.

Conclusion. Application of combined enteral and peroral feeding in patients after pancreaticoduodenectomy has no advantages upon a peroral one. Early peroral feeding promotes the reduction of immunological reactivity of organism as an answer on operative trauma, and the proteins levels, comparing with combined feeding in patients in postoperative period up to the 7th day do not differ essentially.

Author Biographies

A. V. Skums, Shalimov National Institute of Surgery and Transplantology, Kyiv

Anatolii Skums, MD, DSci(Med)
Chief of Department of combined pathology and retroperitoneal surgery,
Shalimov National Institute of Surgery and Transplantology,
30 Heroiv Sevastopolya Str., 03680, Kyiv, Ukraine,
+38 (044)4542079
email: skums.av@gmail.com
https://orcid.org/0000-0002-3477-7809

V. O. Kuzmenko, Shalimov National Institute of Surgery and Transplantology, Kyiv

Viktoriia Kuzmenko, MD, Surgeon,
Department of combined pathology and retroperitoneal surgery,
Shalimov National Institute of Surgery and Transplantology,
30 Heroiv Sevastopolya Str., 03680, Kyiv, Ukraine,
+38 (044)4542079
email: blimmm.melamori@gmail.com
https://orcid.org/0000-0002-5462-261X

A. A. Stasenko, Shalimov National Institute of Surgery and Transplantology, Kyiv

Alina Stasenko, DSci(Biol)
Professor Department of Microbiology and Immunology
Institute of Biology and Medicine,
64/13, Volodymyrska Str., 01601, Kyiv, Ukraine, tel.:
+38 (044) 5213231
alina_stasenko@ukr.net
https://orcid.org/0000-0003-0847-1547

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Published
2020-05-26
How to Cite
Skums, A. V., Kuzmenko, V. O., & Stasenko, A. A. (2020). The impact of early peroral feeding on concentration of the serum interleukin–6 in patients after pancreaticoduodenectomy. Klinicheskaia Khirurgiia, 87(1-2), 19-23. https://doi.org/10.26779/2522-1396.2020.1-2.19
Section
General Problems of Surgery