C-reactive protein and procalcitonin - laboratory markers of degrees of severity and complications of an acute necrotic pancreatitis
Abstract
Objective. To conduct comparative estimation of efficacy of C-reactive protein and procalcitonin as laboratory markers for stratification of the patients severity state suffering an acute necrotic pancreatitis.
Materials and methods. Prospective cohort investigation, including 151 patients with an acute necrotic pancreatitis, was conducted. Clinical, laboratory and bacteriological investigations were accomplished. The levels of C-reactive protein and procalcitonin were determined in the blood plasm.
Results. The necrotic accumulations infectioning was diagnosed in 89 (58.9%) patients: local purulent complications - in 27, sepsis - in 33,septic shock - in 29. In 62 patients with sterile pancreonecrosis a C-reactive protein concentration have raised from (5.6 ± 0.89) to (206 ± 29) mg/l (p˂0.001). Development of purulent-septic complications was accompanied by significant and trustworthy (p<0.01) elevation of procalcitonin concentration: in the patients with sepsis - up to (5.05 ± 0.92) ng/ml, in the patients with septic shock - up to (7.25 ± 2.15) ng/ml.
Conclusion. Simultaneous measurement of levels of C-reactive protein and procalcitonin in the blood plasm in patients, suffering acute necrotic pancreatitis, gives permission to determine the inflammatory process character and stratify the disease severity in its early terms.
References
Usenko OY, Kopchak VM, Khomiak IV, Khomiak AI, Malik AV. Results of surgical treatment of paraduodenal (groove) pancreatitis. Klin Khir. 2019;85(11):5-8. doi:10.26779/2522-1396.2018.11.05
Dronov OI, Nastashenko IL, Susak YM, Tsymbalyuk RS, Tyulyukin IO. Surgical treatment of patients, suffer in an acute biliary pancreatitis and biliary hypertension. Klin Khir. 2018;85(4):5-8. doi: 10.26779/2522-1396.2018.04.05.
Yang CJ, Chen J, Phillips AR, Windsor JA, Petrov MS. Predictors of severe and critical acute pancreatitis: a systematic review. Dig Liv Dis. 2014;46(5):446-51. doi:10.1016/j.dld.2014.01.158.
Holub M, Džupová O, Růžková M, Stráníková A, Bartáková E, Máca T, et al. Selected Biomarkers Correlate with the Origin and Severity of Sepsis. Med Infl. 2018;2018:7028267. doi:10.1155/2018/7028267.
Sproston NR, Ashworth JJ. Role of C-Reactive Protein at Sites of Inflammation and Infection. Front Immun. 2018;9:754. doi:10.3389/fimmu.2018.00754.
Twomey M, Fleming H, Moloney F, Murphy K, Crush L, O'Neill S, et al. C-reactive protein and radiographic findings of lower respiratory tract infection in infants. World J Rad. 2017;9(4):206-11. doi:10.4329/wjr.v9.i4.206.
Covington EW, Roberts MZ, Dong J. Procalcitonin Monitoring as a Guide for Antimicrobial Therapy: A Review of Current Literature. Pharmacotherapy. 2018;38(5):569-81. doi:10.1002/phar.2112.
This work is licensed under a Creative Commons Attribution 4.0 International License.