Perspectives of lymphotropic antibioticotherapy in acute pancreatitis

I. D.  Duzhyi; N. D.  AlYamani; O. V.  Kravets; G. I.  Pyatikop; I. A.  Myslovskyi

doi:10.26779/2522-1396.2020.3-4.18

I. D. Duzhyi Medical Institute of Sumy State University https://orcid.org/0000-0002-4995-0096
N. D. AlYamani Medical Institute of Sumy State University https://orcid.org/0000-0002-8480-3155
O. V. Kravets Medical Institute of Sumy State University https://orcid.org/0000-0003-3394-6671
G. I. Pyatikop Medical Institute of Sumy State University https://orcid.org/0000-0003-4043-0470
I. A. Myslovskyi Sumy Regional Clinical Hospital https://orcid.org/0000-0002-2692-4645

DOI: https://doi.org/10.26779/2522-1396.2020.3-4.18

Keywords: acute pancreatitis; lymphotropic therapy

Abstract

Objective. To study up the possibilities of improvement of the treatment results in patients, suffering an acute pancreatitis, using the method of delivery of antibiotic to pancreatic gland.

Materials and methods. The authors have proposed and conducted the experimental investigation on 20 male rats, consisting of the manners to deliver of ceftriaxone towards pancreatic gland.

Results. Taking into account the enhances antibacterial efficacy of pancreatic gland homogenate, than while antibiotic delivery using other methods, there appear that lymphotropic therapy owes a targeted character and must be considered a perspective one.

Conclusion. To three groups of laboratory animals ceftriaxone was prescribed intramuscularly, intraperitoneally and in accordance to lymphotropic method. To the control group of laboratory animals, the fourth one, antibiotic, was not applied. The zone growth retardation for E. Coli, while application of lymphotropic method, comparing with intramuscular and intraperitoneal methods of the preparation delivery, was enhanced.

Author Biographies

I. D. Duzhyi, Medical Institute of Sumy State University

Igor Duzhyi, MD, DSci(Med), Professor,
head of Department of surgery, traumatology, orthopedics, phthisiology.
Sumy State University, Ukraine.
48 Troitska str., 40000, Sumy, Ukraine
+380990081259
Email: gensurgery@med.sumdu.edu.ua
orcid.org/0000-0002-4995-0096

N. D. AlYamani, Medical Institute of Sumy State University

Navras Jamal Ali AlYamani MD, PhD studeny.
Department of surgery, traumatology, orthopedics, phthisiology,
Sumy State University, Ukraine.
48 Troitska str., 40000, Sumy, Ukraine
+380999471916
e-mail: nalyamani87@gmail.com
https://orcid.org/0000-0002-8480-3155

O. V. Kravets, Medical Institute of Sumy State University

Oleksandr Kravets, MD, PhD, Associate Professor,
Department of surgery, traumatology, orthopedics, phthisiology,
Sumy State University, Ukraine.
48 Troitska str., 40000, Sumy, Ukraine
+380501746786
Email: o.kravets@med.sumdu.edu.ua
orcid.org/0000-0003-3394-6671

G. I. Pyatikop, Medical Institute of Sumy State University

Hennadiy Pyatikop, MD, PhD, Associate Professor,
Department of surgery, traumatology, orthopedics, phthisiology,
Sumy State University, Ukraine.
117/49 Petropavlivska str., 40030, Sumy, Ukraine
+380508599518
Email: h.piatykop@med.sumdu.edu.ua
orcid.org/0000-0003-4043-0470

I. A. Myslovskyi, Sumy Regional Clinical Hospital

Igor Myslovskyi, MD, surgeon
surgical department
Sumy Regional Clinical Hospital»,
48 Troitska str., 40000, Sumy, Ukraine
+380954222150
orcid.org/0000-0002-2692-4645

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