Perspectives of lymphotropic antibioticotherapy in acute pancreatitis
Objective. To study up the possibilities of improvement of the treatment results in patients, suffering an acute pancreatitis, using the method of delivery of antibiotic to pancreatic gland.
Materials and methods. The authors have proposed and conducted the experimental investigation on 20 male rats, consisting of the manners to deliver of ceftriaxone towards pancreatic gland.
Results. Taking into account the enhances antibacterial efficacy of pancreatic gland homogenate, than while antibiotic delivery using other methods, there appear that lymphotropic therapy owes a targeted character and must be considered a perspective one.
Conclusion. To three groups of laboratory animals ceftriaxone was prescribed intramuscularly, intraperitoneally and in accordance to lymphotropic method. To the control group of laboratory animals, the fourth one, antibiotic, was not applied. The zone growth retardation for E. Coli, while application of lymphotropic method, comparing with intramuscular and intraperitoneal methods of the preparation delivery, was enhanced.
Nychytaylo MYu, Andriuschenko DV, Mahlovanyj VA, Andriuschenko VP.
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