Prognostication of complications in patients with diseases of gallbladder after laparoscopic cholecystectomy

Keywords: laparoscopic cholecystectomy; complications; prognostication; factors of risk.


Objective. To elaborate a prognostic classification of possibilities for occurrence of іntra- and postoperative complications, basing on determination of a premorbid state and the risk factors, concerning operative intervention in patients, suffering surgical diseases of gallbladder.

Маterials and methods. Retrospective analysis of treatment of 911 patients, suffering cholelithiasis disease, оperated by the laparoscopic cholecystectomy procedure, was conducted, and factors of possibility of occurrence for іntra- and postoperative complications were determined with further establishment of their criteria.

Results. The factors of risk for the complications occurrence after laparoscopic cholecystectomy in patients with diseases of gallbladder (n=911) were investigated. Prognostication pattern of the complications occurrence was built, taking into account the results of correlation-regression analysis conducted, and on its base the clinic-epidemiological groups of the complications risk were formatted with determination of their frequency of confidence intervals.

Conclusion. Theoretical substantiation and scientific-practical decision of the task was presented, concerning raising of efficacy of miniinvasive operative interventions in patients with diseases of gallbladder, using elaborated methods of prophylaxis and surgical treatment of complications.

Author Biographies

М. А. Каshtalyan, Оdessa National Medical University

Kashtalyan M. MD, DSci, Professor
Head of department of general and military surgery
Odessa Medical National University
9 Pastera Str, Odesa, Ukraine

А. E. Тkachenko, Ukrainian Military-Medical Academy, Kyiv

Tkachenko Andrii, MD, PhD, Senior lecturer
Department of Military Surgery,
Ukranian Military Medical Academy,
45/1, Moscow St., Kyiv 01015, Ukraine;
(044) 280-00-34, (044) 280-01-43;;

О. А. Кvasnevskiy, Оdessa National Medical University

Kvasnevskiy Oleksandr, MD, assistant
Department general and military surgery
Odessa National Medical University
9 Pastera Str, Odesa, Ukraine

А.О. Коlotvin, Оdessa National Medical University

Kolotvin Andrei, MD, assistant
Department general and military surgery
Odessa National Medical University
9 Pastera Str, Odesa, Ukraine


Connor S, Garden J. Changing the Culture of Cholecystectomy. World J Surg. 2016 Jun;40(6):1535. doi: 10.1007/s00268-015-3225-z. PMID: 26304613.

Pucher PH, Brunt LM, Fanelli RD, Asbun HJ, Aggarwal R. SAGES expert Delphi consensus: critical factors for safe surgical practice in laparoscopic cholecystectomy. Surg Endosc. 2015 Nov;29(11):3074-85. doi: 10.1007/s00464-015-4079-z. Epub 2015 Feb 11. PMID: 25669635.

Giger UF, Michel JM, Opitz I, Th Inderbitzin D, Kocher T, Krähenbühl L, et al. Risk factors for perioperative complications in patients undergoing laparoscopic cholecystectomy: analysis of 22,953 consecutive cases from the Swiss Association of Laparoscopic and Thoracoscopic Surgery database. J Am Coll Surg. 2006 Nov;203(5):723-8. doi: 10.1016/j.jamcollsurg.2006.07.018. Epub 2006 Sep 20. PMID: 17084335.

Mohiuddin K, Nizami S, Fitzgibbons RJ Jr, Watson P, Memon B, Memon MA. Predicting iatrogenic gall bladder perforation during laparoscopic cholecystectomy: a multivariate logistic regression analysis of risk factors. ANZ J Surg. 2006 Mar;76(3):130-2. doi: 10.1111/j.1445-2197.2006.03669.x. PMID: 16626349.

Ferreira AR, Queiroz TCN, Vidigal PVT, Ferreira RDP, Wanderley DC, Fagundes EDT. Multivariate Analysis of Biliary Flow-Related Factors and Post-Kasai Survival in Biliary Atresia Patients. Arq Gastroenterol. 2019 May 20;56(1):71-8. doi: 10.1590/S0004-2803.201900000-18. PMID: 31141068.

El-Sharkawy AM, Tewari N, Vohra RS; CholeS Study Group, West Midlands Research Collaborative. The Cholecystectomy As A Day Case (CAAD) Score: A Validated Score of Preoperative Predictors of Successful Day-Case Cholecystectomy Using the CholeS Data Set. World J Surg. 2019 Aug;43(8):1928-34. doi: 10.1007/s00268-019-04981-5. PMID: 31016355.

Colonna AL, Griffiths TM, Robison DC, Enniss TM, Young JB, McCrum ML, et al. Cholecystostomy: Are we using it correctly? Am J Surg. 2019 Jun;217(6):1010-5. doi: 10.1016/j.amjsurg.2019.04.002. Epub 2019 Apr 10. PMID: 31023549.

How to Cite
КаshtalyanМ. А., ТkachenkoА. E., КvasnevskiyО. А., & КоlotvinА. (2020). Prognostication of complications in patients with diseases of gallbladder after laparoscopic cholecystectomy. Klinicheskaia Khirurgiia, 87(7-8), 10-14.
General Problems of Surgery