Нelicobacter pylori as etiological factor of acute pancreatitis and marker of its purulent-septic complications development

Keywords: Helicobacter pylori; acute pancreatitis; purulent-septic complications.

Abstract

Objective. Studying of role of Нelicobacter pylori as etiological factor of acute pancreatitis and marker of development of its purulent-septic complications.

Маterials and methods. Screening investigation was performed in all 124 patients, suffering acute pancreatitis and admitted to hospital; then a screening investigation of Нelicobacter pylori in feces and the blood serological investigation was conducted. In 39 (31.5%) patients bacteriological investigation of biological material for revealing of Нelicobacter pylori was conducted. The patients were distributed into two groups: the main - 66 patients with severe and with a middle severity course of acute pancreatitis and a control one - 58 patients with light course of acute pancreatitis.

Results. Positive results of fecal express-test were obtained in 105 (84.7%) patients. In accordance to the blood serological investigations results in 24 h from the admittance to hospital moment in a control group a positive result was obtained in 8 (13.8%) patients, and in the main - in 23 (34.8%); while in 7 days - in 9 (15.5%) and 42 (63.6%) patients, accordingly. Аntibiotics, which are applied for therapy in purulent-septic complications of acute pancreatitis, guarantee the efficacy of eradication of Нelicobacter pylori in 94.9% patients.

Conclusion. The enhancement of quantity of the blood positive serological investigations by 28.8% (р < 0.001) in patients of the main group in 7 days from the admittance to the hospital date trusts, that Нelicobacter pylori constitutes not the only one etiological factor in acute pancreatitis, but a possible marker of development of its purulent-septic complications as well.

Author Biographies

І. V. Коlosovych, Bogomolets National Medical University, Kyiv

Kolosovych Ihor V. - MD, DSci(Med), Professor,
Professor of Department of Surgery No 2,
Bogomolets National Medical University
01601, 13, T. Shevchenko Blvd, Kyiv, Ukrainе
+38 044 275 67 44
kolosovich_igor@ukr.net
https://orcid.org/0000-0002-2031-4897

І. V. Hanol, Bogomolets National Medical University, Kyiv

Hanol Ihor V. - MD, PhD(Med),
Аssistant of Department of Surgery No 2,
Bogomolets National Medical University
01601, 13, T. Shevchenko Blvd, Kyiv, Ukrainе
+38 044 275 67 44
ganoli@ukr.net
https://orcid.org/0000-0002-3470-2102

К. О. Lebedieva, Bogomolets National Medical University, Kyiv

Lebedieva Kateryna O. - MD, PhD(Med),
Laboratory assistant of Department of Surgery No 2,
Bogomolets National Medical University
01601, 13, T. Shevchenko Blvd, Kyiv, Ukrainе
+38 044 275 67 44
hirurg1607@gmail.com
https://orcid.org/0000-0001-6296-0873

References

Rasslan R, Novo FDCF, Bitran A, Utiyama EM, Rasslan S. Management of infected pancreatic necrosis: state of the art. Rev Col Bras Cir. 2017 Sep-Oct;44(5):521-529. English, Portuguese. doi: 10.1590/0100-69912017005015. PMID: 29019583.

Hollemans RA, Bollen TL, van Brunschot S, Bakker OJ, Ahmed Ali U, van Goor H, et al. Predicting Success of Catheter Drainage in Infected Necrotizing Pancreatitis. Ann Surg. 2016 Apr;263(4):787-92. doi: 10.1097/SLA.0000000000001203. PMID: 25775071.

Forsmark CE, Vege SS, Wilcox CM. Acute Pancreatitis. N Engl J Med. 2016 Nov 17;375(20):1972-1981. doi: 10.1056/NEJMra1505202. PMID: 27959604.

Wolbrink DRJ, Kolwijck E, Ten Oever J, Horvath KD, Bouwense SAW, Schouten JA. Management of infected pancreatic necrosis in the intensive care unit: a narrative review. Clin Microbiol Infect. 2020 Jan;26(1):18-25. doi: 10.1016/j.cmi.2019.06.017. Epub 2019 Jun 22. PMID: 31238118.

Sarsenbaeva AS, Domracheva EV, Rustamov MN. Clinical relevance helicobacter pylori genotypes in patients with chronic pancreatitis and concomitant infections helicobacter pylori. Experimental and Clinical Gastroenterology. 2016;(5):22-27. [In Russian].

Rabelo-Gonзalves EM, Roesler BM, Zeitune JM. Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases. World J Hepatol. 2015 Dec 28;7(30):2968-79. doi: 10.4254/wjh.v7.i30.2968. PMID: 26730276; PMCID: PMC4691700.

Tongtawee T, Kaewpitoon S, Kaewpitoon N, Dechsukhum C, Leeanansaksiri W, Loyd RA, et al. Diagnosis of Helicobacter pylori Infection. Asian Pac J Cancer Prev. 2016;17(4):1631-5. doi: 10.7314/apjcp.2016.17.4.1631. PMID: 27221831.

Malfertheiner P. Diagnostic methods for H. pylori infection: Choices, opportunities and pitfalls. United European Gastroenterol J. 2015 Oct;3(5):429-31. doi: 10.1177/2050640615600968. PMID: 26535120; PMCID: PMC4625752.

Published
2020-09-30
How to Cite
КоlosovychІ. V., HanolІ. V., & LebedievaК. О. (2020). Нelicobacter pylori as etiological factor of acute pancreatitis and marker of its purulent-septic complications development. Klinicheskaia Khirurgiia, 87(7-8), 15-19. https://doi.org/10.26779/2522-1396.2020.7-8.15
Section
General Problems of Surgery