Нelicobacter pylori as etiological factor of acute pancreatitis and marker of its purulent-septic complications development
Abstract
Objective. Studying of role of Нelicobacter pylori as etiological factor of acute pancreatitis and marker of development of its purulent-septic complications.
Маterials and methods. Screening investigation was performed in all 124 patients, suffering acute pancreatitis and admitted to hospital; then a screening investigation of Нelicobacter pylori in feces and the blood serological investigation was conducted. In 39 (31.5%) patients bacteriological investigation of biological material for revealing of Нelicobacter pylori was conducted. The patients were distributed into two groups: the main - 66 patients with severe and with a middle severity course of acute pancreatitis and a control one - 58 patients with light course of acute pancreatitis.
Results. Positive results of fecal express-test were obtained in 105 (84.7%) patients. In accordance to the blood serological investigations results in 24 h from the admittance to hospital moment in a control group a positive result was obtained in 8 (13.8%) patients, and in the main - in 23 (34.8%); while in 7 days - in 9 (15.5%) and 42 (63.6%) patients, accordingly. Аntibiotics, which are applied for therapy in purulent-septic complications of acute pancreatitis, guarantee the efficacy of eradication of Нelicobacter pylori in 94.9% patients.
Conclusion. The enhancement of quantity of the blood positive serological investigations by 28.8% (р < 0.001) in patients of the main group in 7 days from the admittance to the hospital date trusts, that Нelicobacter pylori constitutes not the only one etiological factor in acute pancreatitis, but a possible marker of development of its purulent-septic complications as well.
References
Rasslan R, Novo FDCF, Bitran A, Utiyama EM, Rasslan S. Management of infected pancreatic necrosis: state of the art. Rev Col Bras Cir. 2017 Sep-Oct;44(5):521-529. English, Portuguese. doi: 10.1590/0100-69912017005015. PMID: 29019583.
Hollemans RA, Bollen TL, van Brunschot S, Bakker OJ, Ahmed Ali U, van Goor H, et al. Predicting Success of Catheter Drainage in Infected Necrotizing Pancreatitis. Ann Surg. 2016 Apr;263(4):787-92. doi: 10.1097/SLA.0000000000001203. PMID: 25775071.
Forsmark CE, Vege SS, Wilcox CM. Acute Pancreatitis. N Engl J Med. 2016 Nov 17;375(20):1972-1981. doi: 10.1056/NEJMra1505202. PMID: 27959604.
Wolbrink DRJ, Kolwijck E, Ten Oever J, Horvath KD, Bouwense SAW, Schouten JA. Management of infected pancreatic necrosis in the intensive care unit: a narrative review. Clin Microbiol Infect. 2020 Jan;26(1):18-25. doi: 10.1016/j.cmi.2019.06.017. Epub 2019 Jun 22. PMID: 31238118.
Sarsenbaeva AS, Domracheva EV, Rustamov MN. Clinical relevance helicobacter pylori genotypes in patients with chronic pancreatitis and concomitant infections helicobacter pylori. Experimental and Clinical Gastroenterology. 2016;(5):22-27. [In Russian].
Rabelo-Gonзalves EM, Roesler BM, Zeitune JM. Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases. World J Hepatol. 2015 Dec 28;7(30):2968-79. doi: 10.4254/wjh.v7.i30.2968. PMID: 26730276; PMCID: PMC4691700.
Tongtawee T, Kaewpitoon S, Kaewpitoon N, Dechsukhum C, Leeanansaksiri W, Loyd RA, et al. Diagnosis of Helicobacter pylori Infection. Asian Pac J Cancer Prev. 2016;17(4):1631-5. doi: 10.7314/apjcp.2016.17.4.1631. PMID: 27221831.
Malfertheiner P. Diagnostic methods for H. pylori infection: Choices, opportunities and pitfalls. United European Gastroenterol J. 2015 Oct;3(5):429-31. doi: 10.1177/2050640615600968. PMID: 26535120; PMCID: PMC4625752.

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