STRESS-REACTION IN PATIENTS, WHO STAY IN A COMATOSE STATE
Interrelationship between daily dynamics of stress-hormones and the survival indices in patients, staying in coma due to cerebral insult, was analyzed. There were examined 100 patients, in whom an acute disorder of cerebral blood circulation have had occurred, estimated in accordance to Glasgow coma scale (GCS) as 5-8 points. Concentration of cortisol and prolactin was investigated in the morning and in the evening. Statistically significant difference of the prolactin level in the morning was noted in patients, who have survived and those, who died. In the patients, who stayed in a comatose state as a consequence of an acute cerebral disorders of blood circulation, the expressed stress-reaction with disorder of circadian rhythm of the prolactin level in plasm and of cortisol occurs. The stress hormonal disorders are more expressed in patients with a lethal prognosis in comparison with those, who have survived. The coma depth adversely correlates with cortisol level.