Cytoreductive surgery and hyperthermal intraperitoneal chemoperfusion in colorectal cancer and cancer of ovaries: our experience and perspectives of a new method

Keywords: cytoreductive surgery; hyperthermal intraperitoneal chemoperfusion; colorectal cancer; ovarian cancer; peritoneal canceromatosis.

Abstract

Objective. Studying of results of the cytoreductive operations and hyperthermal intraperitoneal chemoperfusion application for treatment of canceromatosis in colorectal cancer and ovarian cancer.

Materials and methods. In 10 patients, suffering colorectal cancer (6 men and 4 women) were performed peritonectomy, diathermo-ablation of implants, made from visceral peritoneum. Average value of the peritoneal canceromatosis index have constituted 18 (14 - 21). In 11 patients, suffering ovarian cancer, panhisterectomy, peritonectomy, omentectomy, and ablation of the visceral peritoneum implants was conducted. Median value of the peritoneal canceromatosis index was 16 (12 - 20). For hyperthermal intraperitoneal chemoperfusion oxaliplatin was used.

Results. Complete and optimal cytoreduction (degree CC0-CC1 in accordance to classification of P. H. Sugarbaker) was achieved in 5 patients, while suboptimal one (degree CC2) - in 10, and nonoptimal (degree CC3) cytoreduction - in 6 patients. Intraoperative complications were absent. Postoperative complications have occurred in 5 (23.8%) patients: the wound infection, persisting ileus, episode of partial ileus. Of 10 patients, suffering colorectal cancer, 5 died in 9-12 mo. One-year barrier have had survived 45.5% patients. Of 11 women-patients, suffering ovarian cancer, 7 died in 6-24 mo. One-year barrier have had survived 36.4% women-patients.

Conclusion. In patients, suffering colorectal cancer, the survival median was 12 mo, while in the women-patients, suffering ovarian cancer - 18 mo. Cytoreductive operations and hyperthermal intraperitoneal chemoperfusion constitute perspective method for the survival enhancement in patients, suffering canceromatosis, but only if their selection was organized.

Author Biographies

A. V. Malynovskyi, Odessa National Medical University

Malynovskyi Andrii V. MD, DSci (Med), Professor,
Chair of Department of robotic and endoscopic surgery
Odessa National Medical University
22 Nischynskogo str., apt. 96, 65029, Odessa, Ukraine
endosurgery2017@gmail.com
+380663269040
orcid.org/0000-0003-4346-8933

V. V. Grubnik, Odessa National Medical University

Grubnik Volodymyr V. - MD, DSci (Med), Professor,
Head of Department of Surgery №1,
Odessa National Medical University
26 Zabolotnogo Str., 65025, Odesa, Ukraine
+38 094 947 28 29
surgery1@i.ua
orcid.org/0000-0003-4389-908X

I. Z. Gladchuk , Odessa National Medical University

Gladchuk Igor Z. - MD, DSci (Med), Professor,
Head of Department obstetrics and gynecology №1,
Odessa National Medical University
26 Zabolotnogo Str., 65025, Odesa, Ukraine
igor.gladchuk@gmail.com
orcid.org/0000-0003-2926-4125

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Published
2020-10-29
How to Cite
Malynovskyi, A. V., Grubnik, V. V., & Gladchuk , I. Z. (2020). Cytoreductive surgery and hyperthermal intraperitoneal chemoperfusion in colorectal cancer and cancer of ovaries: our experience and perspectives of a new method. Klinicheskaia Khirurgiia, 87(9-10), 54-58. https://doi.org/10.26779/2522-1396.2020.9-10.54
Section
General Problems of Surgery

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