Simulated model of obesity and immediate metabolic disorders after gastric shunting with anastomosis in small laboratory animals

Keywords: obesity; bariatric surgery; gastric minishunting; simulation; anastomosis.

Abstract

Objective. To study metabolic changes and peculiarities of mineral balance depending on the common loop length while constructing of the simulated model of gastric shunting with one anastomosis during 60 days.

Materials and methods. Experimental simulation of gastric minishunting with one anastomosis of various length of bilio-pancreatic loop was constructed on the rats. In 10 rats the anastomosis was formatted on level of half of total length of small intestine (Group I), and also in 10 - a third part of general length of small intestine (Group II). Control Group consisted of 5 rats. The indices of the extra body mass loss and metabolic changes were compared.

Results. In the rats of Group I the index of the body mass loss have constituted 16.6% (41.7 gm), and of the Group II -20.6% (53.2 gm). Lowering of indices of mineral and prion metabolism, comparing preoperative values, was observed in both Groups. Dystrophic changes in osseous tissue of vertebral bodies of lumbar vertebral column were noted in animals of both Groups, more pronounced - in Group II.

Conclusion. The protein and mineral metabolism disorders may be observed not only in large resection volume, but in exclusion of half and more segment of small bowel from general transit, using gastric shunting, what lacks significant advantages in the extra body mass loss, but leads to more profound metabolic disorders.

Author Biographies

R. I. Vynogradov, Shalimov National Institute of Surgery and Transplantology, Kyiv

Vynogradov Moskalenko Roman I. - MD,
Scientific Researcher of Department of Toracoabdominal Surgery
Shalimov National Institute of Surgery and Transplantology,
30 Heroyv Sevastopolya Str., 03680, Kyiv, Ukraine
+38044 4542008
motomotomoto051@gmail.com
https://orcid.org/0000-0002-4204-4744

O. S. Tyvonchuk, Shalimov National Institute of Surgery and Transplantology, Kyiv

Tyvonchuk Olexandr S. - MD, DSci (Med)
Shalimov National Institute of Surgery and Transplantology,
30 Heroyv Sevastopolya Str., 03680, Kyiv, Ukraine
+380505047127
o.tyvonchuk@gmail.com
https://orcid.org/0000-0002-6835-891X

K. O. Nadiein, Shalimov National Institute of Surgery and Transplantology, Kyiv

Nadiein Kostiantyn O. -
intern of Department of Toracoabdominal Surgery
Shalimov National Institute of Surgery and Transplantology,
30 Heroyv Sevastopolya Str., 03680, Kyiv, Ukraine
+380501019272;
kostyanadein@icloud.com
https://orcid.org/0000-0002-0683-3965

V. V. Moskalenko, Shalimov National Institute of Surgery and Transplantology, Kyiv

Moskalenko Vitalii V. - MD,
Surgeon of Department of Toracoabdominal Surgery
Shalimov National Institute of Surgery and Transplantology,
30 Heroyv Sevastopolya Str., 03680, Kyiv, Ukraine
+380635912655;
uml_forever@ukr.net
https://orcid.org/0000-0002-6228-7057

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Published
2020-10-29
How to Cite
Vynogradov, R. I., Tyvonchuk, O. S., Nadiein, K. O., & Moskalenko, V. V. (2020). Simulated model of obesity and immediate metabolic disorders after gastric shunting with anastomosis in small laboratory animals. Klinicheskaia Khirurgiia, 87(9-10), 84-88. https://doi.org/10.26779/2522-1396.2020.9-10.84
Section
Experimental Investigations