Endogenous intoxication indicators in advanced peritonitis and their correction
Objective. To study the lipid peroxidation processes and endogenous intoxication indicators in patients with widespread peritonitis before surgery and during the treatment.
Materials and methods. The study included 97 patients (43 men and 54 women) aged from 17 to 69 years with purulent peritonitis. According to treatment scheme, patients were divided into two groups. Patients in group 1 received standard treatment, and in patients in group 2 standard treatment was supplemented by immunoreactions. The concentration of diene conjugates and malonic dialdehyde, reduced glutathione, catalase activity and the concentration of medium molecular weight peptides were determined in the blood of patients and almost healthy people.
Results. The concentration of diene conjugates, malonic dialdehyde and medium molecular weight peptides in the blood of patients with advanced peritonitis increased significantly depending on the clinical stage of the disease, while the activity of the enzyme catalase and the concentration of reduced glutathione were decreased.
Conclusions. Immunoreactions in combination with standard treatment leads to normalization of lipid peroxidation and reduction of endogenous intoxication on the 5th and 10th days of treatment.
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