Endogenous intoxication indicators in advanced peritonitis and their correction

Keywords: widespread peritonitis; lipid peroxidation; medium molecular peptides.

Abstract

ObjectiveTo study the lipid peroxidation processes and endogenous intoxication indicators in patients with widespread peritonitis before surgery and during the treatment.

Materials and methods. The study included 97 patients (43 men and 54 women) aged from 17 to 69 years with purulent peritonitis. According to treatment scheme, patients were divided into two groups. Patients in group 1 received standard treatment, and in patients in group 2 standard treatment was supplemented by immunoreactions. The concentration of diene conjugates and malonic dialdehyde, reduced glutathione, catalase activity and the concentration of medium molecular weight peptides were determined in the blood of patients and almost healthy people.

Results. The concentration of diene conjugates, malonic dialdehyde and medium molecular weight peptides in the blood of patients with advanced peritonitis increased significantly depending on the clinical stage of the disease, while the activity of the enzyme catalase and the concentration of reduced glutathione were decreased.

Conclusions. Immunoreactions in combination with standard treatment leads to normalization of lipid peroxidation and reduction of endogenous intoxication on the 5th and 10th days of treatment.

Author Biography

E. T. Mammadova, Azerbaijan Medical University, Baku

E. T. Mammadova, Azerbaijani Medical University, Baku
Mammadova Esmira Tarverdi, MD.
Chief laboratory of department of surgical diseases III.
General surgeon of Surgical clinic of Azerbaijan Medical University
Surgical clinic of Azerbaijan Medical University.
Azerbaijan Medical University.
155 Samed Vurgun Str., Baku, Azerbaijan
+994 51 923 09 23
mesmira1412@gmail.com
https://orcid.org/0000-0001-7503-8917

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Published
2021-03-28
How to Cite
Mammadova, E. T. (2021). Endogenous intoxication indicators in advanced peritonitis and their correction. Klinicheskaia Khirurgiia, 88(1-2), 39-44. https://doi.org/10.26779/2522-1396.2021.1-2.39
Section
General Problems of Surgery