Impact of the small bowel impassability on expression of the hypoxia-induced factor-1α
Objective. Studying of the hypoxia-induced factor-1α expression and peritoneal oxygenation in experimental small bowel intestinal impassability.
Materials and methods. The investigation was done on 18 laboratory animals, in which 62 metrics of direct oxymetry performed with the objective to study the impact of the small bowel impassability on velocity of the mass transduction and partial pressure of oxygen and the hypoxia-induced factor-1α expression, influenced by hypoxia.
Results. In experimental ileus, complete or partial one, partial pressure and velocity of the oxygen mass-transduction in peritoneum were statistically significantly lower, than such in a control, indicating on inhibition of cellular structures, utilizing the oxygen, what promotes the adhesive disease occurrence. Experimental ileus have led to lowering of the oxygen partial pressure in peritoneum by 88% - from 28.7 (in a control) to 3.5 mm Hg (p<0.01). The partial (by 277.8%) and the complete (by 248.2%) experimental ileus was characterized by enhancement of the hypoxia-induced factor-1α expression.
Conclusion. Ileus, accompanied by change in the parietal and visceral peritoneum oxygenation, stimulates the abdominal cavity adhesive process development.
Ong AW, Myers SR. Early postoperative small bowel obstruction: A review. Am J Surg. 2020 Mar;219(3):535-9. doi: 10.1016/j.amjsurg.2019.11.008. Epub 2019 Nov 8. PMID: 31735260.
Strajina V, Kim BD, Zielinski MD. Small bowel obstruction in a virgin abdomen. Am J Surg. 2019 Sep;218(3):521-6. doi: 10.1016/j.amjsurg.2019.02.011. Epub 2019 Feb 12. PMID: 30885455.
Wang P, Guan D, Zhang XP, Liu F, Wang W. Modeling the regulation of p53 activation by HIF-1 upon hypoxia. FEBS Lett. 2019 Sep;593(18):2596-611. doi: 10.1002/1873-3468.13525. Epub 2019 Jul 16. PMID: 31282018.
Bower KL, Lollar DI, Williams SL, Adkins FC, Luyimbazi DT, Bower CE. Small Bowel Obstruction. Surg Clin North Am. 2018 Oct;98(5):945-71. doi: 10.1016/j.suc.2018.05.007. Epub 2018 Aug 7. PMID: 30243455.
Behman R, Nathens AB, Haas B, Look Hong N, Pechlivanoglou P, Karanicolas P. Population-based study of the impact of small bowel obstruction due to adhesions on short- and medium-term mortality. Br J Surg. 2019 Dec;106(13):1847-54. doi: 10.1002/bjs.11284. Epub 2019 Aug 9. PMID: 31397896.
Edwards MK, Kuppler CS, Croft CA, Eason-Bates HM. Adhesive Closed-loop Small Bowel Obstruction. Clin Pract Cases Emerg Med. 2018 Jan 9;2(1):31-4. doi: 10.5811/cpcem.2017.10.35927. PMID: 29849259; PMCID: PMC5965135.
Medvecz AJ, Dennis BM, Wang L, Lindsell CJ, Guillamondegui OD. Impact of Operative Management on Recurrence of Adhesive Small Bowel Obstruction: A Longitudinal Analysis of a Statewide Database. J Am Coll Surg. 2020 Apr;230(4):544-51.e1. doi: 10.1016/j.jamcollsurg.2019.12.006. Epub 2020 Jan 17. PMID: 31954815; PMCID: PMC7103552.
Rohwer N, Jumpertz S, Erdem M, Egners A, Warzecha KT, Fragoulis A, et al. Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis. Oncogene. 2019 Jul;38(28):5670-85. doi: 10.1038/s41388-019-0816-4. Epub 2019 May 1. PMID: 31043706.
This work is licensed under a Creative Commons Attribution 4.0 International License.