Analysis of modern methods of analgesia in wide hepatic resection


Analysis of modern methods of analgesia in wide hepatic resection

Author Biography

R. А. Zatsarynnyi , Shalimov National Institute of Surgery and Transplantology, Kyiv

Zatsarynnyi Roman A.- MD,
Head of the intensive therapy department
A. A. Shalimov National Institute of Surgery and Transplantology,
30 Heroyv Sevastopolya Str., 03680, Kyiv, Ukraine
+38 044 497 1374


Novell R, Baker D, Goddard N, editors. Kirk’s general surgical operations. 6th ed. London: Elsevier; 2013. 680 p. ISBN: 9780702044816.

Simmonds PC, Primrose JN, Colquitt JL, Garden OJ, Poston GJ, Rees M. Surgical resection of hepatic metastases from colorectal cancer: a systematic review of published studies. Br J Cancer. 2006 Apr 10;94(7):982-99. doi: 10.1038/sj.bjc.6603033. PMID: 16538219; PMCID: PMC2361241.

Page A, Rostad B, Staley CA, Levy JH, Park J, Goodman M, et al. Epidural analgesia in hepatic resection. J Am Coll Surg. 2008 Jun;206(6):1184-92. doi: 10.1016/j.jamcollsurg.2007.12.041. Epub 2008 Apr 14. PMID: 18501817.

Mallett SV, Sugavanam A, Krzanicki DA, Patel S, Broomhead RH, Davidson BR, et al. Alterations in coagulation following major liver resection. Anaesthesia. 2016 Jun;71(6):657-68. doi: 10.1111/anae.13459. Epub 2016 Mar 31. PMID: 27030945.

Matot I, Scheinin O, Eid A, Jurim O. Epidural anesthesia and analgesia in liver resection. Anesth Analg. 2002 Nov;95(5):1179-81, table of contents. doi: 10.1097/00000539-200211000-00009. PMID: 12401587.

Kehlet H, Holte K. Effect of postoperative analgesia on surgical outcome. Br J Anaesth. 2001 Jul;87(1):62-72. doi: 10.1093/bja/87.1.62. PMID: 11460814.

van Dam RM, Hendry PO, Coolsen MM, Bemelmans MH, Lassen K, Revhaug A, et aloup. Initial experience with a multimodal enhanced recovery programme in patients undergoing liver resection. Br J Surg. 2008 Aug;95(8):969-75. doi: 10.1002/bjs.6227. PMID: 18618897.

Brown EN, Pavone KJ, Naranjo M. Multimodal General Anesthesia: Theory and Practice. Anesth Analg. 2018 Nov;127(5):1246-58. doi: 10.1213/ANE.0000000000003668. PMID: 30252709; PMCID: PMC6203428.

Shontz R, Karuparthy V, Temple R, Brennan TJ. Prevalence and risk factors predisposing to coagulopathy in patients receiving epidural analgesia for hepatic surgery. Reg Anesth Pain Med. 2009 Jul-Aug;34(4):308-11. doi: 10.1097/AAP.0b013e3181ac7d00. PMID: 19574863.

Weinberg L, Scurrah N, Gunning K, McNicol L. Postoperative changes in prothrombin time following hepatic resection: implications for perioperative analgesia. Anaesth Intensive Care. 2006 Aug;34(4):438-43. doi: 10.1177/0310057X0603400405. PMID: 16913338.

Moraca RJ, Sheldon DG, Thirlby RC. The role of epidural anesthesia and analgesia in surgical practice. Ann Surg. 2003 Nov;238(5):663-73. doi: 10.1097/ PMID: 14578727; PMCID: PMC1356143.

Sanford DE, Hawkins WG, Fields RC. Improved peri-operative outcomes with epidural analgesia in patients undergoing a pancreatectomy: a nationwide analysis. HPB (Oxford). 2015 Jun;17(6):551-8. doi: 10.1111/hpb.12392. Epub 2015 Feb 28. PMID: 25728855; PMCID: PMC4430787.

Pöpping DM, Elia N, Marret E, Remy C, Tramèr MR. Protective effects of epidural analgesia on pulmonary complications after abdominal and thoracic surgery: a meta-analysis. Arch Surg. 2008 Oct;143(10):990-9; discussion 1000. doi: 10.1001/archsurg.143.10.990. PMID: 18936379.

Motamed C, Farhat F, Rémérand F, Stéphanazzi J, Laplanche A, Jayr C. An analysis of postoperative epidural analgesia failure by computed tomography epidurography. Anesth Analg. 2006 Oct;103(4):1026-32. doi: 10.1213/01.ane.0000237291.30499.32. PMID: 17000824.

Oguro A, Taniguchi H, Daidoh T, Itoh A, Tsukuda N, Takahashi T. Factors relating to coagulation, fibrinolysis and hepatic damage after liver resection. HPB Surg. 1993 Aug;7(1):43-9. doi: 10.1155/1993/91843. PMID: 8260434; PMCID: PMC2423674.

Lim HJ, Koay CK, Lee LS. Postoperative coagulopathy after liver resection--implications for epidural analgesia. Anaesth Intensive Care. 2006 Feb;34(1):118-9. PMID: 16494163.

Tsui SL, Yong BH, Ng KF, Yuen TS, Li CC, Chui KY. Delayed epidural catheter removal: the impact of postoperative coagulopathy. Anaesth Intensive Care. 2004 Oct;32(5):630-6. doi: 10.1177/0310057X0403200503. PMID: 15535484.

Stanworth SJ, Grant-Casey J, Lowe D, Laffan M, New H, Murphy MF, et a. The use of fresh-frozen plasma in England: high levels of inappropriate use in adults and children. Transfusion. 2011 Jan;51(1):62-70. doi: 10.1111/j.1537-2995.2010.02798.x. Epub 2010 Aug 27. PMID: 20804532.

Morisaki H, Doi J, Ochiai R, Takeda J, Fukushima K. Epidural hematoma after epidural anesthesia in a patient with hepatic cirrhosis. Anesth Analg. 1995 May;80(5):1033-5. doi: 10.1097/00000539-199505000-00031. PMID: 7726401.

Stamenkovic DM, Jankovic ZB, Toogood GJ, Lodge JP, Bellamy MC. Epidural analgesia and liver resection: postoperative coagulation disorders and epidural catheter removal. Minerva Anestesiol. 2011 Jul;77(7):671-9. Epub 2008 Nov 27. PMID: 19037193.

Gogarten W, Vandermeulen E, Van Aken H, Kozek S, Llau JV, Samama CM, et al. Regional anaesthesia and antithrombotic agents: recommendations of the European Society of Anaesthesiology. Eur J Anaesthesiol. 2010 Dec;27(12):999-1015. doi: 10.1097/EJA.0b013e32833f6f6f. PMID: 20890208.

Vandermeulen E. Regional anaesthesia and anticoagulation. Best Pract Res Clin Anaesthesiol. 2010 Mar;24(1):121-31. doi: 10.1016/j.bpa.2009.09.004. PMID: 20402175.

Vandermeulen EP, Van Aken H, Vermylen J. Anticoagulants and spinal-epidural anesthesia. Anesth Analg. 1994 Dec;79(6):1165-77. doi: 10.1213/00000539-199412000-00024. PMID: 7978443.

Horlocker TT, Heit JA. Low molecular weight heparin: biochemistry, pharmacology, perioperative prophylaxis regimens, and guidelines for regional anesthetic management. Anesth Analg. 1997 Oct;85(4):874-85. doi: 10.1097/00000539-199710000-00031. PMID: 9322474.

Amini N, Kim Y, Hyder O, Spolverato G, Wu CL, Page AJ, et al. A nationwide analysis of the use and outcomes of perioperative epidural analgesia in patients undergoing hepatic and pancreatic surgery. Am J Surg. 2015 Sep;210(3):483-91. doi: 10.1016/j.amjsurg.2015.04.009. Epub 2015 Jun 2. PMID: 26105799; PMCID: PMC4695995.

Kasivisvanathan R, Abbassi-Ghadi N, Prout J, Clevenger B, Fusai GK, Mallett SV. A prospective cohort study of intrathecal versus epidural analgesia for patients undergoing hepatic resection. HPB (Oxford). 2014 Aug;16(8):768-75. doi: 10.1111/hpb.12222. Epub 2014 Jan 28. PMID: 24467320; PMCID: PMC4113260.

Weinger MB, Lee LA. No patient shall be harmed by opioid-induced respiratory depression. [Proceedings of “Essential Monitoring Strategies to Detect Clinically Significant Drug-Induced Respiratory Depression in the Postoperative Period” Conference]. APSF Newsletter. 2011;26:20.

Hamill JF, Bedford RF, Weaver DC, Colohan AR. Lidocaine before endotracheal intubation: intravenous or laryngotracheal? Anesthesiology. 1981 Nov;55(5):578-81. doi: 10.1097/00000542-198111000-00016. PMID: 7294413.

Dunn LK, Durieux ME. Perioperative Use of Intravenous Lidocaine. Anesthesiology. 2017 Apr;126(4):729-737. doi: 10.1097/ALN.0000000000001527. PMID: 28114177.

Sun Y, Li T, Wang N, Yun Y, Gan TJ. Perioperative systemic lidocaine for postoperative analgesia and recovery after abdominal surgery: a meta-analysis of randomized controlled trials. Dis Colon Rectum. 2012 Nov;55(11):1183-94. doi: 10.1097/DCR.0b013e318259bcd8. Erratum in: Dis Colon Rectum. 2013 Feb;52(2):271. PMID: 23044681.

Kranke P, Jokinen J, Pace NL, Schnabel A, Hollmann MW, Hahnenkamp K, et al. Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery. Cochrane Database Syst Rev. 2015 Jul 16;(7):CD009642. doi: 10.1002/14651858.CD009642.pub2. Update in: Cochrane Database Syst Rev. 2018 Jun 04;6:CD009642. PMID: 26184397

McCarthy GC, Megalla SA, Habib AS. Impact of intravenous lidocaine infusion on postoperative analgesia and recovery from surgery: a systematic review of randomized controlled trials. Drugs. 2010 Jun 18;70(9):1149-63. doi: 10.2165/10898560-000000000-00000. PMID: 20518581.

Weibel S, Jokinen J, Pace NL, Schnabel A, Hollmann MW, Hahnenkamp K, et al. Efficacy and safety of intravenous lidocaine for postoperative analgesia and recovery after surgery: a systematic review with trial sequential analysis. Br J Anaesth. 2016 Jun;116(6):770-83. doi: 10.1093/bja/aew101. PMID: 27199310.

Earls B, Bellil L. Systemic lidocaine: an effective and safe modality for postoperative pain management and early recovery. APSF Newsletter. 2019;33(1):28-30.

Hollmann MW, Durieux ME. Local anesthetics and the inflammatory response: a new therapeutic indication? Anesthesiology. 2000 Sep;93(3):858-75. doi: 10.1097/00000542-200009000-00038. PMID: 10969322.

Cassuto J, Sinclair R, Bonderovic M. Anti-inflammatory properties of local anesthetics and their present and potential clinical implications. Acta Anaesthesiol Scand. 2006 Mar;50(3):265-82. doi: 10.1111/j.1399-6576.2006.00936.x. PMID: 16480459.

Butterworth JF 4th, Strichartz GR. Molecular mechanisms of local anesthesia: a review. Anesthesiology. 1990 Apr;72(4):711-34. doi: 10.1097/00000542-199004000-00022. PMID: 2157353.

Olschewski A, Hempelmann G, Vogel W, Safronov BV. Blockade of Na+ and K+ currents by local anesthetics in the dorsal horn neurons of the spinal cord. Anesthesiology. 1998 Jan;88(1):172-9. doi: 10.1097/00000542-199801000-00025. PMID: 9447870.

Aguilar JS, Criado M, De Robertis E. Inhibition by local anesthetics, phentolamine and propranolol of [3H]quinuclydinyl benzylate binding to central muscarinic receptors. Eur J Pharmacol. 1980 Dec 5;68(3):317-26. doi: 10.1016/0014-2999(80)90529-4. PMID: 7202495.

Bittencourt AL, Takahashi RN. Mazindol and lidocaine are antinociceptives in the mouse formalin model: involvement of dopamine receptor. Eur J Pharmacol. 1997 Jul 9;330(2-3):109-13. doi: 10.1016/s0014-2999(97)00182-9. PMID: 9253942.

Sinclair R, Eriksson AS, Gretzer C, Cassuto J, Thomsen P. Inhibitory effects of amide local anaesthetics on stimulus-induced human leukocyte metabolic activation, LTB4 release and IL-1 secretion in vitro. Acta Anaesthesiol Scand. 1993 Feb;37(2):159-65. doi: 10.1111/j.1399-6576.1993.tb03693.x. PMID: 8383401.

Rimbäck G, Cassuto J, Wallin G, Westlander G. Inhibition of peritonitis by amide local anesthetics. Anesthesiology. 1988 Dec;69(6):881-6. doi: 10.1097/00000542-198812000-00013. PMID: 3195759.

Yanagi H, Sankawa H, Saito H, Iikura Y. Effect of lidocaine on histamine release and Ca2+ mobilization from mast cells and basophils. Acta Anaesthesiol Scand. 1996 Oct;40(9):1138-44. doi: 10.1111/j.1399-6576.1996.tb05577.x. PMID: 8933856.

Hendrickson HS, van Dam-Mieras MC. Local anesthetic inhibition of pancreatic phospholipase A2 action on lecithin monolayers. J Lipid Res. 1976 Jul;17(4):399-405. PMID: 133195.

Hendrickson HS. The penetration of local anesthetics into phosphatidylcholine monolayers. J Lipid Res. 1976 Jul;17(4):393-8. PMID: 133194.

Kunze H, Bohn E, Vogt W. Effects of local anaesthetics on prostaglandin biosynthesis in vitro. Biochim Biophys Acta. 1974 Sep 19;360(3):260-9. doi: 10.1016/0005-2760(74)90055-1. PMID: 4278080.

Horrobin DF, Manku MS. Roles of prostaglandins suggested by the prostaglandin agonist/antagonist actions of local anaesthetic, anti-arrhythmic, anti-malarial, tricyclic anti-depressant and methyl xanthine compounds. Effects on membranes and on nucleic acid function. Med Hypotheses. 1977 Mar-Apr;3(2):71-86. doi: 10.1016/0306-9877(77)90057-3. PMID: 197384.

Jönsson A, Cassuto J, Tarnow P, Sinclair R, Bennett A, Tavares IA. Effects of amide local anaesthetics on eicosanoid formation in burned skin. Acta Anaesthesiol Scand. 1999 Jul;43(6):618-22. doi: 10.1034/j.1399-6576.1999.430605.x. PMID: 10408815.

Kaba A, Laurent SR, Detroz BJ, Sessler DI, Durieux ME, Lamy ML, et al. Intravenous lidocaine infusion facilitates acute rehabilitation after laparoscopic colectomy. Anesthesiology. 2007 Jan;106(1):11-8; discussion 5-6. doi: 10.1097/00000542-200701000-00007. PMID: 17197840.

Marret E, Rolin M, Beaussier M, Bonnet F. Meta-analysis of intravenous lidocaine and postoperative recovery after abdominal surgery. Br J Surg. 2008 Nov;95(11):1331-8. doi: 10.1002/bjs.6375. PMID: 18844267.

Vigneault L, Turgeon AF, Côté D, Lauzier F, Zarychanski R, Moore L, et al. Perioperative intravenous lidocaine infusion for postoperative pain control: a meta-analysis of randomized controlled trials. Can J Anaesth. 2011 Jan;58(1):22-37. doi: 10.1007/s12630-010-9407-0. PMID: 21061107.

Koppert W, Ostermeier N, Sittl R, Weidner C, Schmelz M. Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action. Pain. 2000 Mar;85(1-2):217-24. doi: 10.1016/s0304-3959(99)00268-7. PMID: 10692621.

McNicol ED, Tzortzopoulou A, Cepeda MS, Francia MB, Farhat T, Schumann R. Single-dose intravenous paracetamol or propacetamol for prevention or treatment of postoperative pain: a systematic review and meta-analysis. Br J Anaesth. 2011 Jun;106(6):764-75. doi: 10.1093/bja/aer107. Epub 2011 May 9. PMID: 21558067.

Swenson BR, Gottschalk A, Wells LT, Rowlingson JC, Thompson PW, Barclay M, et al. Intravenous lidocaine is as effective as epidural bupivacaine in reducing ileus duration, hospital stay, and pain after open colon resection: a randomized clinical trial. Reg Anesth Pain Med. 2010 Jul-Aug;35(4):370-6. doi: 10.1097/AAP.0b013e3181e8d5da. PMID: 20588151.

Terkawi AS, Tsang S, Kazemi A, Morton S, Luo R, Sanders DT, et al. A Clinical Comparison of Intravenous and Epidural Local Anesthetic for Major Abdominal Surgery. Reg Anesth Pain Med. 2016 Jan-Feb;41(1):28-36. doi: 10.1097/AAP.0000000000000332. PMID: 26650426; PMCID: PMC5467154.

Kuo CP, Jao SW, Chen KM, Wong CS, Yeh CC, Sheen MJ, et al. Comparison of the effects of thoracic epidural analgesia and i.v. infusion with lidocaine on cytokine response, postoperative pain and bowel function in patients undergoing colonic surgery. Br J Anaesth. 2006 Nov;97(5):640-6. doi: 10.1093/bja/ael217. Epub 2006 Sep 4. PMID: 16952918.

De Oliveira GS Jr, Duncan K, Fitzgerald P, Nader A, Gould RW, McCarthy RJ. Systemic lidocaine to improve quality of recovery after laparoscopic bariatric surgery: a randomized double-blinded placebo-controlled trial. Obes Surg. 2014 Feb;24(2):212-8. doi: 10.1007/s11695-013-1077-x. PMID: 24036842.

Wallin G, Cassuto J, Högström S, Lindén I, Faxén A, Rimbäck G, et al. Effects of lidocaine infusion on the sympathetic response to abdominal surgery. Anesth Analg. 1987 Oct;66(10):1008-13. PMID: 3631561.

Hans GA, Lauwick SM, Kaba A, Bonhomme V, Struys MM, Hans PC, et al. Intravenous lidocaine infusion reduces bispectral index-guided requirements of propofol only during surgical stimulation. Br J Anaesth. 2010 Oct;105(4):471-9. doi: 10.1093/bja/aeq189. Epub 2010 Jul 21. PMID: 20650919.

Bazin P, Padley J, Ho M, Stevens J, Ben-Menachem E. The effect of intravenous lidocaine infusion on bispectral index during major abdominal surgery. J Clin Monit Comput. 2018 Jun;32(3):533-539. doi: 10.1007/s10877-017-0035-x. Epub 2017 Jun 16. PMID: 28623471.

How to Cite
Zatsarynnyi R. А. (2021). Analysis of modern methods of analgesia in wide hepatic resection. Klinicheskaia Khirurgiia, 88(9-10), 80-85.